釉质发育不全与结合上皮附着异常相关性研究进展

Advances on the Relationship between Amelogenesis Imperfecta and Abnormal Attachment of Junctional Epithelium

釉质发育不全为遗传性釉质病变,导致釉质的多种结构异常。正常情况下,结合上皮附着在釉牙骨质界。在生理结构和组织发生学上,釉质与结合上皮都有着密不可分的联系,且某种釉质发育不全相关基因缺失、蛋白缺陷,如αvβ6整合素、牙成釉细胞相关蛋白(odontogenic ameloblast-associated protein,ODAM)、釉成熟蛋白(amelotin,AMTN)、富含脯氨酸-谷氨酰胺分泌性钙结合蛋白1(secretory calcium-binding phosphoprotein proline-glutamine rich 1,SCPPPQ1),均可引起结合上皮的附着异常。本文从釉质与结合上皮的组织学联系、釉质发育不全与结合上皮附着异常相关的机制做一综述。

Amelogenesis imperfecta is a hereditary enamel lesion,which causes various structural abnormalities of enamel.Normally,the junctional epithelium attaches to the cemento-enamel junction.In terms of physiological structure and histogenesis,enamel is closely related to the binding epithelium,and certain enamel dysplasia related genes and protein defects,such as αvβ6 integrin,odontogenic ameloblast-associated protein (ODAM),amelotin (AMTN),and secretory calcium binding phosphoprotein proclin-glutamine rich 1 (SCPPPQ1),can cause adhesion abnormality of the binding epithelium.This article reviews the histological relationship between enamel and binding epithelium and the mechanism of enamel hypoplasia and binding epithelium adhesion abnormality.