来氟米特联合依那西普治疗类风湿性关节炎的效果及对患者血沉、C反应蛋白及类风湿因子水平的影响

Effect of Leflunomide Combined with Etanercept in the Treatment of Rheumatoid Arthritis and Its Influence on Erythrocyte Sedimentation Rate,C-reactive Protein and Rheumatoid Factor Levels in Patiens

目的:探讨类风湿性关节炎(rheumatoid arthritis,RA)患者应用来氟米特联合依那西普治疗的效果及对其血沉、C反应蛋白及类风湿因子水平的影响。方法:选取2019年4月-2020年4月本院收治的类风湿性关节炎患者108例,按照随机数字表法分为研究组和对照组,各54例。对照组应用依那西普治疗,研究组应用来氟米特联合依那西普治疗。比较两组在治疗后的关节功能指标、实验室检查指标、临床疗效和骨代谢指标。结果:研究组关节肿胀、关节疼痛例数均少于对照组,关节晨僵时间短于对照组,双手握力高于对照组,差异均有统计学意义(P<0.05)。研究组血沉、C反应蛋白和类风湿因子均低于对照组,差异均有统计学意义(P<0.05)。研究组临床总有效率高于对照组,差异有统计学意义(P<0.05)。研究组骨代谢指标均优于对照组,差异均有统计学意义(P<0.05)。结论:在类风湿性关节炎患者治疗中应用来氟米特联合依那西普疗效明显,可以改善关节功能,控制病情发展,有效降低了C反应蛋白、类风湿因子及血沉水平,安全性高,值得临床进一步应用推广。

Objective:To explore the effect of Leflunomide combined with Etanercept in the treatment of rheumatoid arthritis (RA),and its influence on erythrocyte sedimentation rate,C-reactive protein and rheumatoid factor levels.Method:A total of 108 cases of rheumatoid arthritis patients admitted to our hospital from April 2019 to April 2020 were selected,they were divided into the study group and the control group according to random number table method,54 cases in each group.The control group was treated with Etanercept,the study group was treated with Leflunomide combined with Etanercept.The indexes of joint function,laboratory examination,clinical efficacy and bone metabolism after treatment were compared between two groups.Result:The number of cases of joint swelling and joint pain in the study group were lower than those in the control group,the time of joint stiffness in the morning was shorter than that in the control group,the grip strength of both hands was higher than that in the control group,there were statistically significant differences (P<0.05).In the study group,erythrocyte sedimentation rate,C-reactive protein and rheumatoid factor were all lower than those in the control group,the differences were statistically significant (P<0.05).The total clinical effective rate of the study group was higher than that of the control group,the difference was statistically significant (P<0.05).Bone metabolism indexes of the study group were better than those of the control group,the differences were statistically significant (P<0.05).Conclusion:The application of Leflunomide combined with Etanercept in the treatment of patients with rheumatoid arthritis has obvious curative effect,can improve joint function,control the development of the disease,effectively reduce C-reactive protein,rheumatoid factor and erythrocyte sedimentation rate levels,high safety,it’s worthy of further clinical application and promotion.