丙戊酸钠缓释片联合左乙拉西坦对癫痫患者智力水平及生活能力的影响

Effect of Sodium Valproate Sustained Release Tablets Combined with Levetiracetam on Intelligence Level and Living Ability of Epilepsy

目的:探讨丙戊酸钠缓释片联合左乙拉西坦对癫痫患者智力水平及生活能力的影响。方法:选择2018年3月-2019年3月在本院收治的58例癫痫患者为研究对象,回顾性分析其临床资料,根据治疗方式不同分为对照组29例与研究组29例。对照组应用丙戊酸钠缓释片治疗,研究组应用丙戊酸钠缓释片联合左乙拉西坦治疗。比较两组治疗效果、不良反应发生率、智力水平及生活能力。结果:研究组治疗总有效率为96.6%,高于对照组的75.9%(P<0.05);研究组不良反应发生率为6.9%,与对照组的6.9%相比,差异无统计学意义(P>0.05)。两组治疗前血磷、血钙水平相比,差异均无统计学意义(P>0.05);研究组治疗后血磷、血钙水平均低于对照组(P<0.05)。两组治疗前ADL、MoCA、MMSE评分相比,差异均无统计学意义(P>0.05);研究组治疗后ADL、MoCA、MMSE评分均高于对照组(P<0.05)。两组治疗前癫痫发作持续时间与发作次数比较,差异均无统计学意义(P>0.05);研究组治疗后癫痫发作持续时间与发作次数均低于对照组(P<0.05)。结论:癫痫应用丙戊酸钠缓释片联合左乙拉西坦治疗效果理想,能提高治疗效果的同时不增加不良反应,从而有利于患者智力水平与生活能力的改善,同时能降低血磷与血钙水平,改善癫痫持续时间与发作次数,提高了患者的预后,值得临床中进一步推广和应用。

Objective:To investigate the effect of Sodium Valproate Sustained Release Tablets combined with Levetiracetam on intelligence level and living ability of epileptic patients.Method:A total of 58 epileptic patients in our hospital from March 2018 to March 2019 were selected as the research objects,and their clinical data were retrospectively analyzed.According to different treatment methods,they were divided into the control group (n=29) and study group (n=29).The control group was treated with Sodium Valproate Sustained-release Tablets,and the study group was treated with Sodium Valproate Sustained Release Tablets combined with Levetiracetam.The treatment effect,incidence of adverse reactions,intelligence level and living ability of two groups were compared.Result:The total effective rate in the study group was 96.6%,it was higher than 75.9% in the control group (P<0.05);the incidence of adverse reactions in the study group was 6.9%,compared with 6.9% in the control group,the difference was not statistically significant (P>0.05).There were no significant differences in the levels of blood phosphorus and calcium between two groups before treatment (P>0.05);after treatment,the levels of blood phosphorus and calcium in the study group were lower than those in the control group (P<0.05).There were no significant differences in ADL,MOCA and MMSE scores between two groups before treatment (P>0.05);after treatment,the scores of ADL,MOCA and MMSE in the study group were higher than those in the control group (P<0.05).There were no significant differences in seizure duration and seizure times between two groups before treatment (P<0.05);after treatment,the duration and seizure times of the study group were lower than those of the control group (P<0.05).Conclusion:The effect of Sodium Valproate Sustained Release Tablets combined with Levetiracetam in the treatment of epilepsy is ideal,which can improve the treatment effect without increasing adverse reactions,which is conducive to the improvement of intelligence level and living ability of patients,reduce the levels of blood phosphorus and calcium,improve the duration of epilepsy and seizure times,and improve the prognosis of patients,which is worthy of further promotion and application in clinical practice.