动脉粥样硬化性缺血性脑血管病患者外周血TNF-α,IL-6,IL-8和WBC水平与慢性失眠症PSQI的相关性研究

Correlation between Levels of TNF-α,IL-6,IL-8 and WBC in Peripheral Blood of Patients with Atherosclerotic Ischemic Cerebrovascular Disease and PSQI in Chronic Insomnia

目的分析动脉粥样硬化性缺血性脑血管病患者外周血肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)和白细胞(WBC)水平与慢性失眠症匹兹堡睡眠质量批数(PSQI)的相关性。方法将103例动脉粥样硬化性缺血性脑血管病患者(2019年1~12月收治)分为不伴失眠症组(PSQI评分≤10分,共66例)和伴失眠症组(PSQI评分>10分,共37例)。不伴失眠症组和伴失眠症组均未经治疗行外周血TNF-α,IL-6,IL-8和WBC检测,分析两组的外周血TNF-α,IL-6,IL-8,WBC和PSQI评分差异,采用Pearson秩相关法分析外周血TNF-α,IL-6,IL-8和WBC与PSQI评分之间的相关性。结果伴失眠症组的TNF-α(26.49±4.82 nmol/L),IL-6(16.92±3.44 pg/ml),IL-8(21.45±3.87 pg/ml)和PSQI(16.74±2.25分)高于不伴失眠症组(22.19±4.64 nmol/L,13.62±3.03 pg/ml,17.91±3.14 pg/ml和6.91±1.93分),伴失眠症组的WBC[(6.41±1.28)×109/L]低于不伴失眠症组[(8.76±1.46)×109/L],经t检验分析差异均具有统计学意义(t=4.450~9.098,均P<0.05)。外周血TNF-α,IL-6和IL-8水平均与PSQI呈正相关,经Pearson秩相关法分析(r=0.8743~0.9339,P<0.05);外周血WBC水平与PSQI呈负相关,经Pearson秩相关法分析(r=-0.8430,P=0.000)。结论动脉粥样硬化性缺血性脑血管病并发慢性失眠症患者具有明显的炎症反应和白细胞浸润,且炎症反应、白细胞浸润的程度越高,并发慢性失眠症的程度越严重。

Objective To analyze the correlation between the levels of TNF-α,IL-6,IL-8 and WBC in peripheral blood of patients with atherosclerotic ischemic cerebrovascular disease and chronic insomnia pittsburgh sleep quality index(PSQI).Methods A total of 103 patients with arteriosclerosis ischemic cerebrovascular disease(admitted from January to December 2019)were divided into two groups:no insomnia group(PSQI≤10,66 cases)and insomnia group(PSQI>10,37 cases).Peripheral blood TNF-α,IL-6,IL-8 and WBC were detected in both the non-insomnia group and the insomnia group without treatment,and differences in peripheral blood TNF-α,IL-6,IL-8,WBC and PSQI scores were analyzed.Pearson rank correlation method was used to analyze the correlation between peripheral blood TNF-α,IL-6,IL-8,WBC and PSQI scores.Results The levels of TNF-α(26.49±4.82 nmol/ml),IL-6(16.92±3.44 pg/ml),IL-8(21.45±3.87 pg/ml)and PSQI(16.74±2.25 point)in the insomnia group were higher than those in the insomnia group(22.19±4.64 nmol/ml,13.62±3.03 pg/ml,17.91±3.14 pg/ml and 6.91±1.93 point).The WBC of the insomnia group(6.41±1.28×109/L)was lower than that of the insomnia group(8.76±1.46109/l),and the difference was statistically significant after t-test analysis(t=4.450~9.098,all P<0.05).The levels of TNF-α,IL-6 and IL-8 in peripheral blood were positively correlated with PSQI,and were analyzed by Pearson rank correlation method(r=0.8743~0.9339,all P<0.05).WBC level in peripheral blood was negatively correlated with PSQI,which was analyzed by Pearson rank correlation method(r=-0.8430,P=0.000).Conclusion Patients with atherosclerotic ischemic cerebrovascular disease complicated with chronic insomnia had obvious inflammatory reaction and leukocyte infiltration,and the higher the intensity of inflammatory reaction and leukocyte infiltration,the more serious the degree of chronic insomnia.