血清中microRNA-106b对宫颈癌患者的早期诊断及预后预测价值

Value Analysis of Serum microRNA-106b in Early Diagnosis of Cervical Cancer

目的探究宫颈癌(cervical cancer,CC)组织中microRNA-106b的表达与患者临床病理特征及总体生存率(overall survival,OS)的关系。方法选取2017年9月~2019年11月西安市第四医院妇产科收治的经病理学确诊的CC患者150例为研究对象,比较microRNA-106b在CC组织和癌旁正常组织中的相对表达量,并分析不同水平microRNA-106b与CC患者临床病理特征和OS之间的关系。结果microRNA-106b在CC组织中的相对表达量为0.075,显著高于癌旁正常组织中的相对表达量0.003(P=0.0186)。不同水平microRNA-106b与CC患者的年龄、肿瘤直径、FIGO分期无关(P>0.05),与淋巴结转移和分化程度有密切关系,差异有统计学意义(χ2=13.95,7.21,P<0.05)。microRNA-106b高表达组患者的OS显著低于microRNA-106b低表达组,其差异具有统计学意义(P=0.036)。结论microRNA-106b与CC的发生、发展有密切关系,其对CC的诊治及预后有关键作用。

Objective To explore the correlation between the expression of microRNA-106b in cervical cancer(CC)tissue and the clinicopathological features and overall survival(OS)of the patients.Methods A total of 150 pathologically confirmed CC patients admitted to the department of Obstetrics and Gynecology of Xi'an Fourth Hospital from September 2017 to November 2019 were selected as study subjects.The relative expression levels of microrNa-106b in CC tissues and adjacent normal tissues were compared,and the relationship between different levels of microrNa-106b and the clinicopathological characteristics and OS of CC patients was analyzed.Results The relative expression level of microRNA-106b in CC tissues was 0.075,which was significantly higher than 0.003 in adjacent normal tissues(P=0.0186).MicroRNA-106b of different levels was not related to age,tumor diameter and FIGO stage of CC patients(P>0.05),but was closely related to lymph node metastasis and differentiation degree(χ2=13.95,7.21,P<0.05).The OS of patients with high microRNA-106b expression group was significantly lower than that of patients with low microRNA-106b expression group,and the difference was statistically significant(P=0.036).Conclusion MicroRNA-106b is closely related to the occurrence and development of CC,and plays a key role in the diagnosis,treatment and prognosis of CC.