血清瘦素、网膜素-1及血小板内皮细胞黏附分子在原发性高血压早期肾损害患者中的表达及其意义

Expression and significance of serum leptin,omentin-1 and platelet endothelial cell adhesion molecule-1 in patients with early renal damage in essential hypertension

目的研究血清瘦素(LEP)、网膜素-1(Omentin-1)与及血小板内皮细胞黏附分子1(sPECAM-1)在原发性高血压早期肾损害患者中的表达及其意义。方法选取2018年3月~2019年10月新疆医科大学第一附属医院收治的72例原发性高血压合并早期肾功能损害患者为A组,73例单纯早期肾损害患者为B组,81例原发性高血压肾功能正常患者为C组,38例同期健康体检者为D组,分析四组的空腹血糖、三酰甘油、总胆固醇、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血清胱抑素(Cys-C)、24 h尿微量清蛋白(MAU)、尿素氮(BUN)、肌酐(Cr)、LEP、Omentin-1及sPECAM-1水平的差异,使用ROC曲线对患者的LEP、Omentin-1及sPECAM-1联合诊断效能分析。结果四组的MAU、BUN、Cr从高到低依次为A、B、C、D组;四组的LEP、Omentin-1及sPECAM-1水平从高到低依次为A、B、C、D组,联合检测的灵敏度及特异度高于单独检测,ROC曲线显示,高血压性早期肾脏损伤LEP、Omentin-1、sPECAM-1的临界值分别为7.99、59.60、7.91μg/L。结论通过对患者LEP、Omentin-1、sPECAM-1水平变化,对原发性高血压早期肾功能损害患者有显著指导性诊断意义。

Objective To study the expression and significance of serum leptin(LEP),Omentin-1 and platelet endothelial cell adhesion molecule-1(sPECAM-1)in patients with early renal damage in essential hypertension.Methods From March 2018 to October 2019,72 patients with primary hypertension and early renal impairment treated in the First Affiliated Hospital of Xinjiang Medical University were selected as group A,73 patients with simple early renal impairment as group B,81 patients with normal renal function of primary hypertension as group C,38 patients with physical examination at the same time as group D.Fasting blood glucose,triglyceride,total cholesterol,high-density lipoprotein(HDL),low densith lipoprotein(LDL),serum cystatin c(Cys-C),micro-albumin urine(MAU),blood urea nitrogen(BUN),creatinine(Cr),LEP,Omentin-1 and sPECAM-1 were analyzed in four groups.The ROC curve was used to analyze the efficiency of joint diagnosis of LEP,Omentin-1 and sPECAM-1.Results The MAU,BUN and Cr levels of the four groups from high to low were group A,B,C and D;the LEP,Omentin-1 and sPECAM-1 levels of the four groups from high to low were group A,B,C and D.The sensitivity and specificity of combined detection were higher than those of single detection.ROC curve showed that the critical values of LEP,Omentin-1 and sPECAM-1 of hypertensive early renal injury were 7.99,59.60 and 7.91μg/L respectively.Conclusion Through the changes of LEP,Omentin-1 and sPECAM-1 levels,it has significant guiding significance for the early renal function damage patients with essential hypertension.