小柴胡颗粒联合HAART治疗艾滋病的临床疗效研究

Clinical efficacy of Xiaochaihu Granules combined with HAART in the treatment of acquired immune deficiency syndrome

目的探讨小柴胡颗粒联合高效抗逆转录病毒治疗(HAART)方式治疗艾滋病的临床效果。方法选取2017年6月~2018年10月九江市第三人民医院收治80例艾滋病患者作为研究对象,按随机数字表法将其分为治疗组和对照组,每组各40例。对照组患者行HAART治疗,治疗组患者在此基础上加用小柴胡颗粒治疗,两组均连续治疗18个月。比较两组患者的免疫功能、临床疗效、免疫重建成功率、不良反应发生情况。结果治疗后,治疗组患者的CD4+T淋巴细胞计数为(390.28±21.27)个/μL、CD4+/CD8+为(0.62±0.05),高于对照组的(335.26±35.19)个/μL、(0.46±0.03),差异有统计学意义(P<0.05);治疗组患者治疗后的CD8+T淋巴细胞计数为(620.57±34.52)个/μL,低于对照组的(750.27±26.64)个/μL,差异有统计学意义(P<0.05);治疗组患者的治疗总有效率、免疫重建成功率分别为90.00%、82.50%,高于对照组的70.00%、60.00%,差异有统计学意义(P<0.05);两组的头痛、呕吐发生率比较,差异无统计学意义(P>0.05);治疗组的恶心、骨髓抑制发生率低于对照组,差异有统计学意义(P<0.05)。结论小柴胡颗粒联合HAART治疗艾滋病可增强治疗效果,改善免疫功能,提高免疫重建成功率,减少不良反应发生。

Objective To investigate the clinical efficacy of Xiaochaihu Granules combined with highly active anti-retroviral therapy(HAART)in the treatment of acquired immune deficiency syndrome.Methods A total of 80 cases of acquired immune deficiency syndrome patients treated in the Third People′s Hospital of Jiujiang City from June 2017 to October 2018 were selected as subjects.They were divided into treatment group and control group according to random number table method,40 cases in each group.The control group was treated with HAART,and the treatment group was treated with Xiaochaihu Granules on the basis of the control group.Both groups were treated continuously for 18 months.The immune function,clinical efficacy,success rate of immune reconstruction and adverse reactions were compared between the two groups.Results After treatment,the number of CD4+T lymphocytes in the treatment group was(390.28±21.27)cells/μL,and the CD4+/CD8+in the treatment group was(0.62±0.05),which were higher than those in the control group of(335.26±35.19)cells/μL and(0.46±0.03),and the differences were statistically significant(P<0.05).The CD8+T lymphocytes in the treatment group was(620.57±34.52)cells/μL,which was lower than(750.27±26.64)cells/μL in the control group,and the difference was statistically significant(P<0.05).The total effective rate and the success rate of immune reconstruction in the treatment group were 90.00%and 82.50%respectively,which were higher than 70.00%and 60.00%of the control group,the differences were statistically significant(P<0.05).The rates of headache and vomiting were not significantly different between the two groups(P>0.05).The rates of nausea and marrow suppression in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Xiaochaihu Granules combined with HAART in the treatment of acquired immune deficiency syndrome can enhance the therapeutic effect,improve the immune function,improve the success rate of immune reconstruction and reduce the incidence of adverse reactions.