补肾祛风湿法对类风湿关节炎患者肠道微生态的影响研究

Study on the influence of kidney nourishing and dampness disinhibiting therapy on intestinal microecology of patients with rheumatoid arthritis

目的探讨补肾祛风湿法对类风湿关节炎(RA)患者肠道微生态的影响。方法选取九江市第一人民医院2017年1月~2018年12月收治的80例RA患者为研究对象,采用随机数字表法分为对照组与观察组,每组各40例。对照组口服甲氨蝶呤治疗,观察组口服尪痹片治疗,均治疗3个月。比较两组的疗效、肠道菌群多样性以及安全指标(药物不良反应、血常规、尿常规以及肝肾功能指标)。结果治疗3个月后,观察组的总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗3个月后,观察组的肠道菌群均匀度为(0.99±0.06)E,丰富度为(22.68±3.08)S,均高于对照组的(0.90±0.05)E、(19.36±2.16)S,差异有统计学意义(P<0.05)。观察组的不良反应发生率为2.50%,低于对照组的20.00%,差异有统计学意义(P<0.05)。结论补肾祛风湿法治疗RA能显著提高治疗效果,恢复患者肠道微生态多样性,药物安全性更高,能促进患者康复,值得推广。

Objective To investigate the influence of kidney nourishing and dampness disinhibiting therapy on the intestinal microecology of patients with rheumatoid arthritis(RA).Methods A total of 80 RA patients treated in Jiujiang First People′s Hospital from January 2017 to December 2018 were selected as the research objects,and they were divided into the control group and the observation group according to random number table method,40 cases in each group.The control group was treated with Methotrexate,and the observation group was treated with Wangbi Tablets,all patients were treated for 3 months.The efficacy,intestinal flora diversity and safety indicators(adverse drug reactions,blood routine,urine routine,liver and kidney function)of the two groups were compared.Results After 3 months of treatment,the total effective rate of the observation group was 97.50%,which was higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the uniformity of the intestinal flora of the observation group was(0.99±0.06)E,and richness of the intestinal flora of the observation group was(22.68±3.08)S,which were higher than those of the control group([0.90±0.05]E and[19.36±2.16]S),the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 2.50%,which was lower than 20.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Kidney nourishing and dampness disinhibiting therapy in the treatment of RA can significantly improve the therapeutic effect,restore the patients′intestinal micro-ecological diversity,has higher safety of use of drug,can promote the recovery of patients,and which is worthy of promotion.