日本《川崎病诊断指南第6次修订版》要点解读

Interpretation of Revision of Diagnostic Guidelines for Kawasaki Disease (6th revised edition)

川崎病(KD)是儿童时期一种急性全身非特异性血管炎,未经治疗的KD患儿约有25%发生冠状动脉瘤或扩张,可导致缺血性心脏病或猝死,已成为发达地区儿童获得性心脏病最常见的病因。由于KD的诊断主要依赖于临床特征,因此,KD的及早诊断,尤其是不完全性KD,仍面临挑战。该文结合国内临床实践情况,对日本循环学会科学委员会修订发表的《川崎病诊断指南第6次修订版》要点问题给予解读,并与2017年美国心脏病学会(AHA)颁布的KD诊断的科学声明进行对比,希望对提高国内KD诊断水平有所帮助。

Kawasaki disease(KD)is an acute nonspecific generalized vasculitis in childhood.About 25%of untreated KD patients may develop coronary artery dilatation or aneurysm,which may lead to ischemic heart disease or sudden death,and it has become the leading cause of acquired heart disease in children in most developed areas worldwide.Because the diagnosis of KD mainly depends on clinical features,early diagnosis of KD,especially incomplete KD,is still a big challenge.The authors interpret the key points of Revision of Diagnostic Guidelines for Kawasaki Disease(6th revised edition)delivered by the Scientific Committee of the Japanese Circulation Society,and compared with the Scientific Statement for KD diagnosis by the American Heart Association(2017),aiming to improve the diagnostic level of KD in domestic clinical practice.