郑州孤独症谱系障碍儿童营养状况

Nutritional status of children with autism spectrum disorders in Zhengzhou

目的研究孤独症谱系障碍儿童营养状况,为改善孤独症谱系障碍儿童营养提供参考。方法选取2016年9月—2018年9月在郑州大学附属儿童医院收治的孤独症谱系障碍儿童120例(孤独症谱系障碍组),选择同期健康儿童120例(健康组)。采用克氏孤独症行为量表(Clancy Autism Behavior Scale,CABS)评估儿童状况,调查血清营养素及营养状况。结果与健康组比,孤独症谱系障碍组儿童维生素A[(83.44±9.20,59.45±4.42)mg/L]、维生素B6[(64.15±11.22,32.02±5.75)mg/L]、维生素C[(60.62±10.26,47.63±13.12)mg/L]、蛋白质[(120.45±30.51,104.46±9.38)g/L]、铁[(134.25±18.16,112.17±6.02)mg/L]、钙[(72.96±10.62,66.57±4.11)mg/L]、锌[(70.85±5.76,62.52±10.66)mg/L]、叶酸[(31.38±6.77,20.29±6.26)mg/L]、二十二碳五烯酸[(0.72±0.22,0.55±0.14)μmol/L]、二十二碳六烯酸[(1.54±0.35,1.22±0.26)μmol/L]、花生四烯酸[(5.51±0.76,5.03±0.16)μmol/L]均明显降低(t值分别为25.75,27.92,8.54,5.49,12.64,6.30,7.53,13.18,7.14,8.04,6.77,P值均<0.05),低体质量(49.17%,63.33%)、消瘦(38.33%,46.67%)检出率明显增高(χ^2值分别为4.89,6.71,P值均<0.05)。结论孤独症谱系障碍儿童营养状况与正常儿童存在差别,血清营养素缺乏。

Objective To investigate the nutritional status of children with autism spectrum disorders,and to provide a reference for improving their nutritional status.Methods 120 children with autism spectrum disorder who were treated in the rehabilitation center of Affiliated Children’s Hospital of Zhengzhou University from September 2016 to September 2018 were selected as case group,and 120 normal children in the physical examination center of the same hospital were selected as the healthy group.The children’s status was assessed by using the Clancy Autism Behavior Scale(CABS),and the serum nutrients levels were compared between these two groups.Results Compared with the healthy group,the Vitamin A[(83.44±9.20,59.45±4.42)mg/L],Vitamin B6[(64.15±11.22,32.02±5.75)mg/L],Vitamin C[(60.62±10.26,47.63±13.12)mg/L],protein[(120.45±30.51,104.46±9.38)g/L],iron[(134.25±18.16,112.17±6.02)mg/L],calcium[(72.96±10.62,66.57±4.11)mg/L],zinc[(70.85±5.76,62.52±10.66)mg/L]and folic acid[(31.38±6.77,20.29±6.26)mg/L],eicosapentaenoic acid(EPA)[(0.72±0.22,0.55±0.14)μmol/L],decosahexaenoic acid(DHA)[(1.54±0.35,1.22±0.26)μmol/L]and arachidonic acid(AA)[(5.51±0.76,5.03±0.16)μmol/L]were lower(t=25.75,27.92,8.54,5.49,12.64,6.30,7.53,13.18,7.14,8.04,6.77,P<0.05),the low body weight(49.17%,63.33%)and wasting(38.33%,46.67%)in autism spectrum disorder group were higher significantly(χ^2=4.89,6.71,P<0.05).Conclusion The nutritional status of children with autism spectrum disorder is different from that of normal children.The lack of serum nutrients will lead to a high incidence of malnutrition.