miR-409-3p在肿瘤中的研究进展

Research progress of miR-409-3p and tumor

microRNA是一类内源性非编码小RNA,它通过与靶基因的3′端非翻译区(3′UTR)结合,在转录后上调其靶基因的表达,进而调控多种生物学过程。miR-409-3p属于microRNA家族的一员,随着研究的深入,越来越多的证据表明肿瘤中存在异常表达的miR-409-3p,其与肿瘤的发生发展及预后密切相关,在肿瘤细胞增殖、凋亡、血管生成、迁移、侵袭和耐药等过程中发挥重要作用而受到了广泛的关注,近年来其可能作为新的循环标志物而成为研究的热点。本文就miR-409-3p在肿瘤中的研究进展进行综述。

microRNA is a type of endogenous non-coding small RNA.It binds to the 3′UTR of its target gene at the post-transcriptional level,thereby regulating a variety of organism process.miR-409-3p belongs to a large family of microRNA.With the deepening of research,more and more evidence shows that there is abnormal expression of miR-409-3p in tumors,which is also closely related to the occurrence,development and prognosis of tumors.miR-409-3p and has received extensive attention about its important role in various processes such as tumor cell proliferation,apoptosis,angiogenesis,migration,invasion and the development of drug resistance.In recent years,MiR-409-3p may become a research hot spot as a new circulating marker.This article reviews the research progress of miR-409-3p in tumors.