非编码RNA在膀胱癌中的研究进展

Research progress of non-coding RNA in bladder cancer

膀胱癌是全世界最常见的癌症之一,虽然手术结合化疗和放疗在一定程度上改善了患者的预后,但大多数肌肉浸润性膀胱癌患者的预后仍然很差。而且,膀胱癌的确切机制和关键调节因子尚不清楚。最近的研究表明,一些非编码RNA在膀胱癌中表达失调,对膀胱癌的发生发展起着至关重要的作用。更重要的是,非编码RNA可作为膀胱癌的诊断和预后的生物标志物。本综述旨在总结近期的研究进展,这些研究表明了包括miRNA、lncRNA、circRNA在内的三类非编码RNA在膀胱癌中的调控机制,以及它们作为临床诊断或预后生物标志物的潜在作用。

Bladder cancer is one of the most common cancers in the world.Although the prognosis of patients to a certain extent has been improved by surgery combined with chemotherapy and radiotherapy,the prognosis of most patients with muscle-invasive bladder cancer is still poor.Moreover,the exact mechanism and key regulators of bladder cancer are unclear.Recent studies have shown that some non-coding RNAs are dysregulated in bladder cancer and play crucial roles in the development of bladder cancer.More importantly,non-coding RNA can be used as a biomarker for the diagnosis and prognosis of bladder cancer.This review aims to summarize recent research progress,which indicate the regulatory mechanisms for three types of non-coding RNAs including miRNA,lncRNA,and circRNA in bladder cancer,and their potential roles as biomarkers for clinical diagnosis or prognosis.