浅析肠道菌群与2型糖尿病及冠心病的关系

Analysis of the relationship between intestinal flora and type 2 diabetes mellitus and coronary heart disease

糖尿病和冠心病是当前危害公共健康的最普遍的问题,它们的发病率逐年升高。由糖尿病引发的心脑血管、肾、周围神经、眼、足等并发症增加了患者致残或致死的风险。冠心病的常见并发症如心肌梗塞、心源性休克和心力衰竭等,严重时也会危及患者生命。研究表明,肠道菌群紊乱可通过诱发炎症反应、胰岛素抵抗、脂质代谢异常、提高血尿酸水平等途径,增加2型糖尿病和冠心病的发病率,从而影响这些疾病的发展及预后,其诱发2型糖尿病的机制含内毒素机制、短链脂肪酸机制和胆汁酸机制等。本文从肠道菌群失调的角度综述肠道菌群与2型糖尿病及冠心病的关系。

Diabetes mellitus and coronary heart disease are the most common problems endangering public health,and their incidences are increasing year by year.Cardiovascular,renal,neuroperipheral,eye and foot complications caused by diabetes increase the risk of disability or death.Common complications of coronary heart disease,such as myocardial infarction,cardiogenic shock and heart failure,can also endanger patients′lives in severe cases.Studies have shown that intestinal flora disorders can increase the incidence of type 2 diabetes mellitus and coronary heart disease by inducing inflammation,insulin resistance,abnormal lipid metabolism and increasing serum uric acid level,thus affecting the development and prognosis of these diseases.The mechanisms of the induction of type 2 diabetes by them include endotoxin mechanism,short chain fatty acid mechanism and bile acid mechanism.This article introduced the relationship between intestinal flora imbalance and type 2 diabetes mellitus and coronary heart disease.