半乳糖凝集素3在慢性阻塞性肺疾病患者中的水平变化及意义

Changes and significance of Galectin-3 in patients with chronic obstructive pulmonary disease

目的观察半乳糖凝集素3(Galectin-3)在慢性阻塞性肺疾病(COPD)患者中的水平变化,探讨其与肺功能指标、炎性因子水平的关系。方法分别选取40例COPD患者作为观察组、40例健康体检人员作为对照组,检测并比较2组研究对象Galectin-3、炎性因子水平、肺功能情况。结果观察组Galectin-3、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)水平均显著高于对照组(P <0.05);观察组肺功能指标水平显著低于对照组,差异有统计学意义(P <0.05);AECOPD患者Galectin-3水平与hs-CRP、TNF-α、IL-6水平均呈正相关性(P <0.01),与用力肺活量(FVC)、1 s用力呼气容积(FEV1)、FEV1/FVC等肺功能指标均呈负相关性(P <0.05);治疗后,AECOPD患者Galectin-3水平较治疗前明显降低(P <0.05),差异有统计学意义。结论 AECOPD患者体内Galectin-3水平较高,与炎性因子、肺功能相关,可作为AECOPD病情评估的辅助观察指标。

Objective To investigate the level changes of Galectin-3 in patients with chronic obstructive pulmonary disease( COPD),and to investigate the relationship between lung function index and inflammatory factors. Methods A total of 40 patients with COPD admitted to our hospital were selected as subjects,40 health examiners were selected as controls.Galectin-3 level,inflammatory factor and lung function were compared between the two groups. Results The levels of Galectin-3,hs-CRP,TNF-α and IL-6 in the observation group were significantly higher than those in the control group( P <0. 05). The levels of FVC,FEV1 and FEV1/FVC in the observation group were significantly lower than those in the control group,with the differences statistically significant( P < 0. 05). Pearson correlation analysis showed that Galectin-3 levels were positively correlated with hs-CRP,TNF-α,and IL-6 levels( P < 0. 01),while Galectin-3 levels were negatively correlated with FVC,FEV1,and FEV1/FVC levels( P < 0. 05). After treatment,the level of Galectin-3 in AECOPD patients was significantly lower than before treatment,with the differences statistically significant( P < 0. 05). Conclusion The level of Galectin-3 in patients with COPD is high,and it is related to inflammatory factors and lung function. Galectin-3 can be used as an auxiliary observation indicator for the disease severity assessment of AECOPD.