不同机械刺激调控软骨细胞代谢的研究进展

Research progress of different mechanical stimulation regulating chondrocytes metabolism

软骨细胞作为一种力学效应细胞,在体内多轴载荷的刺激下,能够产生多种物理化学信号,从而影响自身的生长、发育和凋亡。为此,模拟体内力学环境成为体外培养软骨细胞的一大研究热点。虽然大量报道已充分证明不同机械刺激能够调控软骨细胞代谢,但对其加载方案尚未达成一致。本篇综述将从不同机械形式出发,探讨不同机械刺激调控软骨细胞代谢的差异性,从而寻找促进软骨细胞生长增殖的优势方案,以制定更为稳定、有效和可靠的实验策略。

As a kind of mechanical effector cells,chondrocytes can produce a variety of physical and chemical signals under the stimulation of multiaxial load in vivo,which affect their own growth,development and apoptosis.Therefore,simulating the mechanical environment in vivo has become a research hotspot in the culture of chondrocytes in vitro.Although a large number of reports have fully proved that different mechanical stimulation can regulate the metabolism of chondrocytes,the loading scheme has not been agreed.Starting from different mechanical forms,this review will explore the differences in the regulation of chondrocyte metabolism by different mechanical stimuli,so as to find an advantage scheme to promote the growth and proliferation of chondrocytes and to develop a more stable,effective and reliable experimental strategy.