GSTs基因多态性与中国人群慢性阻塞性肺疾病易感性Meta分析

GSTs Gene Polymorphisms and Susceptibility to Chronic Obstructive Pulmonary Disease in China:A Meta-analysis

目的:慢性阻塞性肺疾病(COPD)是一种以不完全可逆性气流受限为特征的进行性肺疾病,环境和遗传因素参与COPD的发病机制。先前的研究表明GSTs是与COPD相关的重要易感基因,但是GSTM1、GSTT1和GSTP1 Ile(105)Val基因多态性与COPD之间的关联仍存在争议,目前认为其研究差异性的主要来源为种族和地域的不同,因此我们基于已发表的关于中国人群的病例对照研究进行此meta分析,以评估GSTM1、GSTT1和GSTP1基因多态性与中国人群COPD易感性的关系。方法:对7大数据库:PubMed、EMBASE、Cochrane图书馆、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方数据库(WANFANG)和维普数据库(VIP)进行电子搜索,以获取有关GSTM1、GSTT1和GSTP1 Ile(105)Val基因多态性和COPD风险的文献。结果:共纳入21个研究,包括2356例COPD患者和2164例对照。Meta分析结果显示:GSTM1缺失基因型显著增加了中国人群COPD的风险[OR=1.69,95%CI(1.41,2.04),P<0.05];GSTT1缺失基因型与中国人群COPD的风险无显著关系[OR=1.38,95%CI(1.00,1.89),P=0.05];而GSTM1/GSTT1组合缺失基因型与中国人群COPD风险增加有关[OR=1.75,95%CI(1.12,2.73),P=0.01];GSTP1 Ile(105)Val基因多态性与中国人群COPD的风险无显著相关性,其等位基因模型(G vs A)OR=1.21,95%CI(0.87,1.68),P<0.05;其显性模型(GG+AG vs AA)OR=1.03,95%CI(0.75,1.42),P<0.05。结论:基于最新证据的meta分析,GSTM1缺失基因型、GSTM1/GSTT1组合缺失基因型可能是中国人群COPD发生的危险因素,但仍需更多的大样本的病例对照研究来进一步验证。

Objective:Chronic obstructive pulmonary disease(COPD)is a progressive lung disease characterized by incomplete reversible airflow limitation.Environmental and genetic factors are involved in the pathogenesis of COPD.Previous studies have shown that GSTs is an important susceptibility gene associated with COPD.However,the association between GSTM1,GSTT1 and GSTP1 Ile105Val gene polymorphism and COPD is still controversial.At present,it is believed that the main sources of differences in its research are different races and regions.Therefore,we conducted this meta analysis based on a published case-control study on the Chinese population.To evaluate the relationship between GSTM1,GSTT1 and GSTP1 gene polymorphisms and COPD susceptibility in Chinese population.Method:PubMed,EMBASE,Cochrane Library,CBM,CNKI,WANFANG and VIP Database were searched electronically,and to obtain the literature on GSTM1,GSTT1 and GSTP1 Ile(105)Val gene polymorphism and COPD risk.Results:A total of 21 studies were included,including 2356 patients with COPD and 2164 controls.The results of Meta analysis showed that GSTM1 null genotype significantly increased the risk of COPD in Chinese population[OR=1.69,95%CI(1.41,2.04),P<0.05].There was no significant relationship between GSTT1 null genotype and the risk of COPD in Chinese population[OR=1.38,95%CI(1.00,1.89),P=0.05].Moreover,we also found that the combined GSTM1/GSTT1 null genotypes showed a high association with increased COPD susceptibility[OR=1.75,95%CI(1.12,2.73),P=0.01].The GSTP1 Ile(105)Val polymorphism showed pooled odds ratios for allele model(OR=1.21,95%CI:0.87~1.68,P<0.05),dominant model(OR=1.03,95%CI:0.75~1.42,P<0.05).Conclusions:GSTM1 null genotype and the combined GSTM1/GSTT1 null genotype may be risk factors for the occurrence of COPD in China.But more large sample case-control studies are needed to further verify it.