摘要
莪术醇作为莪术Curcuma rhizoma的重要成分,具有抗病毒、抗炎、抗肿瘤等药理活性,在抗肿瘤研究领域受到了广泛关注。通过查阅近年来国内外相关文献,综述了莪术醇的天然来源、抗肿瘤作用机制及其结构修饰、抗肿瘤活性评价等方面的研究进展,为其进一步的结构优化策略提供新的研究思路。
Curcumol,as an important component of Curcuma Rhizoma,has anti-virus,anti-inflammatory,anti-tumor and other pharmacological activities,which has attracted more and more attentions in anti-tumor research area.The progress on the natural source,anti-tumor mechanism,structural modification,and anti-tumor evaluation of curcumol are reviewed in this paper,which will provide a novel strategy for its further structural optimization.
作者
聂添情
孟祥伟
应宇晨
张兴贤
NIE Tian-qing;MENG Xiang-wei;YING Yu-chen;ZHANG Xing-xian(College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第21期5613-5621,共9页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(21372203)
浙江中医药大学省重点建设高校优势特色学科(中药学)开放基金资助项目(ZYAOXZD2019008)
浙江省新苗人才计划项目(2019R403044)。
关键词
莪术
莪术醇
天然来源
抗肿瘤机制
结构修饰
抗肿瘤活性
Curcuma Rhizoma
curcumol
natural source
anti-tumor action mechanism
structural modification
anti-tumor activity
