地屈孕酮治疗习惯性流产对妊娠结局的改善效果分析

Analysis of the effect of dydrogesterone on the improvement of pregnancy outcome in pregnant women with habitual abortion

目的:分析地屈孕酮治疗习惯性流产对妊娠结局的改善效果。方法:2018年1月-2019年12月收治习惯性流产孕妇30例,随机分为两组,各15例。对照组应用黄体酮治疗;观察组使用地屈孕酮治疗。比较两组临床疗效和妊娠结局。结果:观察组治疗后血清人孕激素诱导阻断因子(PIBF)和人绒毛膜促性腺激素(HCG)水平均明显高于对照组,差异有统计学意义(P<0.05);观察组保胎成功率高于对照组,差异有统计学意义(P<0.05)。结论:地屈孕酮治疗习惯性流产孕妇,能够提高血HCG和PIBF水平,改善患者孕期生理指标水平,从而显著降低流产风险,确保胎儿安全。

Objective:To analyze the effect of dydrogesterone on the improvement of pregnancy outcome in pregnant women with habitual abortion.Methods:From January 2018 to December 2019,30 cases of pregnant women with habitual abortion were enrolled,they were randomly divided into two groups with 15 cases in each group.The control group was treated with progesterone,while the observation group was treated with dydrogesterone.The clinical efficacy and pregnancy outcome of the two groups were compared.Results:After treatment,the levels of progesterone-induced blocking factor(PIBF)and human chorionic gonadotropin(HCG)in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The success rate of fetal preservation in the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:The treatment of habitual abortion pregnant women with dydrogesterone can improve the levels of blood HCG and PIBF,improve the level of physiological indexes during pregnancy period,thus significantly reduce the risk of abortion and ensure the safety of the fetus.