健脾祛湿方外敷治疗小儿脾虚湿蕴型湿疹

Effect of External Application of Jianpi Qushi Formula on Infantile Spleen Deficiency Dampness Accumulation Eczema and Expression of Immunoglobulin,Ifn-gamma and Bcl-6 in Peripheral Blood

目的:探讨健脾祛湿方外敷治疗小儿脾虚湿蕴型湿疹的临床疗效,且对患儿免疫球蛋白及外周血γ干扰素(interferon-γ,IFN-γ)、重组人B细胞淋巴瘤蛋白(recombinant human B cell lymphoma protein,Bcl-6)水平表达的影响。方法:140例脾虚湿蕴型湿疹患儿按随机数字表法分为两组,均为67例。对照组仅予以氯雷他定颗粒治疗,体质量≤30 kg的患儿每次5 mg,体质量30 kg以上的患儿,每次10 mg,饭后温水溶解服用,每天1次。研究组采用健脾祛湿方外敷治疗。比较两组皮损面积、瘙痒程度、中医证候评分、皮损状态、临床疗效、免疫指标、IFN-γ、Bcl-6水平变化情况。结果:两组治疗前皮损面积、瘙痒程度比较,差异无统计学意义(P>0.05),治疗后对照组皮损面积大于研究组,瘙痒程度高于研究组(P<0.05)。治疗前两组证候评分、皮损状态比较,差异无统计学意义(P>0.05),治疗后对照组证候评分、皮损状态均优于研究组(P<0.05),对照组有效率低于研究组(P<0.05)。治疗前两组免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白G(immunoglobulin G,IgG)水平比较,差异无统计学意义(P>0.05),治疗后对照组IgM、IgG水平均高于研究组(P<0.05)。治疗前两组IFN-γ、Bcl-6水平比较,差异无统计学意义(P>0.05),治疗后对照组IFN-γ水平低于研究组,Bcl-6水平高于研究组(P<0.05)。结论:健脾祛湿方外敷治疗小儿脾虚湿蕴型湿疹效果显著。

Objective:To investigate the effect of external application of Jianpi Qushi Formula on children with spleen deficiency and dampness type eczema,immunoglobulin,peripheral blood interferon-γ(IFN-γ),and recombinant human B cell lymphoma protein(recombinant human)B cell lymphoma protein(Bcl-6)level expression.Method:140 children with spleen deficiency and dampness accumulation type eczema were randomly divided into two groups according to the treatment random number table,with 71 cases in the control group and 69 cases in the study group was.During the period,the control group lost 4 cases,the study group lost 2 cases,and the actual cases of the two groups were 67 cases.The control group was only treated with loratadine granules.Children with a body weight less than 30 kg received 5 mg each time,and children with a body weight more than 30 kg received 10 mg each time,dissolved in warm water after meals,once daily,and the study group used In the treatment of external application of Jianpi Qushi Formula,the skin lesion area,pruritus degree,TCM syndrome score,skin lesion status,treatment efficiency,immune index,IFN-γ,Bcl-6 level changes were compared between the two groups.Results:There was no difference in the area of skin lesions and the degree of itching before treatment between the two groups(P>0.05).After treatment,the area of skin lesions in the control group was larger than that in the study group,and the degree of itching was higher than that in the study group(P<0.05).There was no difference in skin lesion status(P>0.05).After treatment,the syndrome score and skin lesion status score of the control group were higher than those of the study group(P<0.05),and the effective rate of the control group was lower than that of the study group(P<0.05).There was no difference in the levels of immunoglobulin M(IgM)and immunoglobulin G(IgG)between the first two groups(P>0.05).After treatment,the levels of IgM and IgG in the control group were higher than those in the study group(P<0.05),there was no difference in IFN-γand Bcl-6 levels between the two groups before treatment(P>0.05).After treatment,the IFN-γlevel in the control group was lower than the study group,and the Bcl-6 level was higher than the study group(P<0.05).Conclusion:In the treatment of children′s eczema with spleen deficiency and dampness accumulation,the external application of Jianpi Qushi Decoction has a significant therapeutic effect,and it is worthy of more extensive clinical application.