瘢痕中生物力学的研究进展

Research progress on mechanobiology of scar

瘢痕是皮肤全层损伤后不可避免的结果,而增生性瘢痕与瘢痕疙瘩是皮肤伤口愈合过程失调的产物,力学因素在决定伤口外观的过程中具有重要作用。通过广泛查阅近年来瘢痕及伤口愈合中涉及的生物力学相关文献,该文就瘢痕形成中的生物力学因素、瘢痕的力学模型以及瘢痕中力学相关治疗进行回顾与总结,并分析未来的发展方向。

Scar is an inevitable consequence of full-thickness skin injury.Hypertrophic scar and keloid are caused by abnormal wound healing.Mechanical factors play an important role in scar formation.An extensive literature review on mechanobiology of scar and wound healing,as well as a summary of the mechanobiological factors of scar formation and treatments,and mechanical model of scar were conducted,with guiding future development in this research field.