反复呼吸道感染患儿血清维生素A E水平的临床研究

Clinical analysis of serum vitamin A and E levels in children with recurrent respiratory tract infection

目的研究反复呼吸道感染(RRTI)患儿血清维生素A、E的水平。方法选取2017年2~12月在安徽省妇幼保健院就诊的120例呼吸道感染患儿作为研究对象,其中反复呼吸道感染患儿60例作为RRTI组,非反复呼吸道感染患儿60例作为非RRTI组,选取同期体检的健康儿童42例作为对照组。比较3组对象血清维生素A、E水平及白细胞计数(WBC)、C反应蛋白(CRP)、血红蛋白(Hb)水平;分析血清维生素A、E水平与血清WBC、CRP、Hb水平的相关性。结果3组对象维生素A、Hb水平进行比较,差异有统计学意义(P<0.05),RRTI组患儿血清维生素A、Hb水平均低于非RRTI组和对照组,差异有统计学意义(P<0.05)。维生素A检测水平分型比较,差异有统计学意义(P<0.05),RRTI组、非RRTI组和对照组血清维生素A缺乏率分别为85.00%、78.33%和40.48%。120例患儿血清维生素A水平与血清Hb水平呈正相关(r=0.186,P=0.018),与血清CRP水平呈负相关(r=-0.205,P=0.009)。结论呼吸道感染儿童存在维生素A缺乏,以RRTI儿童维生素A缺乏最为明显。

Objective To investigate the serum vitamin A and E levels of children with recurrent respiratory tract infections(RRTI).Methods From Feb 2017 to Dec 2017,a total of 120 children with respiratory tract infection in Anhui Women and Child Health Care Hospital were selected as the research objects.Among them,60 children with recurrent respiratory tract infection were RRTI group,60 children with non recurrent respiratory tract infection were non-RRTI group.In addition,42 healthy children with physical examination in the same period were selected as the control group.Serum vitamin A and E levels,deficiencies and white blood cell count(WBC),C-reactive protein(CRP),hemoglobin(Hb)levels in three groups of children were compared.The correlation between serum vitamin A and E levels and serum WBC,CRP and Hb levels was analyzed.Results Serum vitamin A level and Hb level in RRTI group were significantly lower than those in non-RRTI group and the control group.There were statistically significant differences in vitamin A level and Hb level between the three groups(P<0.05).The serum vitamin A deficiency rate of RRTI group,non-RRTI group and control group was 85.00%,78.33%and 40.48%respectively,and the difference in vitamin A detection level was statistically significant(P<0.05).Serum vitamin A levels in 120 children were positively correlated with serum Hb levels(r=0.186,P=0.018)and negatively correlated with serum CRP levels(r=-0.205,P=0.009).Conclusions Vitamin A deficiency occurs in children with respiratory tract infection,especially in RRTI children.