共生菌与肠黏膜屏障互作关系研究进展

Research progress on interactions between commensal microorganisms and the intestinal mucosal barrier

肠黏膜屏障由上皮细胞组成,且被覆盖在上面的宿主分泌黏液层保护,是宿主抵御致病和非致病微生物的第一道防线。微生物在黏膜层中共生或突破黏膜层感染动物机体。文章综述共生菌与肠黏膜屏障的相互作用,旨在应用基于共生菌与肠黏膜作用机制的菌群调控策略来增强黏膜屏障功能。

The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms.The microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection.The paper discusses the interactions of commensal microorganisms and the intestinal mucosal barrier,in order to enhance the mucosal barrier function by the microflora regulation strategy based on the interaction mechanism between commensal microorganisms and intestinal mucosa.