体检人群非酒精性脂肪肝影响因素的双中心病例对照研究

Risk factors for non-alcoholic fatty liver disease in physical examination population:a two-center case-control study

目的探究新疆维吾尔自治区克拉玛依地区与四川成都地区体检人群非酒精性脂肪肝(NAFLD)发病的相关因素,为新疆维吾尔自治区克拉玛依地区与四川省成都地区NAFLD疾病防控提供科学依据。方法纳入268例克拉玛依市人民医院体检中心与四川大学华西医院体检中心体检人群作为研究对象,根据肝脏超声检查分为病例组和对照组,收集两组人群的临床资料并进行统计学分析。结果双中心研究结果显示,病例组体质量指数(BMI)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、空腹血糖(FPG)、尿酸(UA)、三酰甘油(TG)、γ-谷氨酰转移酶(GGT)水平高于对照组,高密度脂蛋白胆固醇(HDL-C)低于对照组,差异均有统计学意义(P<0.05)。Logistic回归分析显示,高BMI、高水平FPG、高水平AST、高水平ALT是NAFLD发病的影响因素(P<0.05)。成都地区体检人群中NAFLD患者较克拉玛依地区年龄更小,且肝脏脂肪变程度更严重。结论高BMI、高水平FPG、高水平AST、高水平ALT是NAFLD发病的影响因素;成都地区NAFLD防控形势较克拉玛依地区更为严峻。

Objective To explore the risk factors of the incidence of non-alcoholic fatty liver disease(NAFLD)in the physical examination population in Karamay of Xinjiang Uygur Autonomous Region and Chengdu of Sichuan,and to provide a scientific basis for the prevention and control of NAFLD disease in Karamay of Xinjiang Uygur Autonomous Region and Chengdu of Sichuan.Methods A total of 268 subjects from Medical Examination Center of the People′s Hospital of Karamay and West China Hospital of Sichuan University were included.All the subjects were divided into case group and control group by liver ultrasonography.The clinical data of two groups were collected and statistically analyzed.Results The comparison between two groups showed that body mass index(BMI),aspartate aminotransferase(AST),alanine aminotransferase(ALT),fasting blood glucose(FPG),uric acid(UA),triglyceride(TG),γ-glutamyl transpeptidase(GGT)were higher than those in the control group,and high-density lipoprotein cholesterol(HDL-C)was lower than that in the control group,and the differences were statistically significant(P<0.05).Logistic regression showed that elevated levels of BMI,FPG,AST,ALT were the influence factors of the incidence NAFLD(P<0.05).NAFLD patients in the physical examination population in Chengdu were younger than those in Karamay and the degree of hepatic steatosis was more serious.Conclusion Elevated levels of BMI,FPG,AST,ALT are influence factors of the incidence of NAFLD.The prevention and control situation of NAFLD in Chengdu is more severe than in Karamay.