基于谨守病机理念之益胃畅气汤治疗慢性萎缩性胃炎临床观察

Clinical Study on Yiwei Changqi Decoction in the Treatment of Chronic Atrophic Gastritis Based on the Concept of Observing Pathogenesis

目的探讨慢性萎缩性胃炎应用“益胃畅气汤”加减治疗的疗效。方法选取2018年6月-2019年5月的60例慢性萎缩性胃炎就诊患者,随机分组,西药对照组采用替普瑞同联合吗丁啉方案治疗,中药观察组采用“益胃畅气汤”随症加减治疗。比较2组慢性萎缩性胃炎治疗前后症状积分改善情况。结果治疗前,进行2组患者胃脘痛、痞闷、嗳气、纳呆症状积分对比,结果显示其差异无统计学意义,具有可比性;治疗后再次比较各症状积分,结果显示,2组各症状治疗后积分均有改善,与治疗前比较,差异具有统计学意义(P<0.05);且观察组积分变化较对照组差异明显(P<0.05),其中嗳气症状治疗积分变化2组差异显著(P<0.01)。观察组临床症状改善的总有效率为96.67%(29/30),显著高于对照组的76.67%(23/30)(P<0.01)。结论“益胃畅气汤”加减能有效缓解慢性萎缩性胃炎患者临床症状,从而改善生活质量,进一步验证了“谨守病机”“因病论治”方法的有效性和可实施性。

Objective To investigate the effect of Yiwei Changqi decoction on chronic atrophic gastritis.Methods 60 patients with chronic atrophic gastritis from June 2018 to may 2019 were collected and randomly divided into two groups.The western medicine observation group was treated with teprenol combined with domperidone,and the traditional Chinese medicine treatment group was treated with Yiwei Changqi decoction.The main symptoms of chronic atrophic gastritis were compared between the two groups before and after treatment.Results Before treatment,two groups of patients with epigastralgia,epigastric distension,belching,anorexia symptom score comparison,the results showed that the difference was not statistically significant.After treatment,the symptom scores were compared again,the results showed that the scores of the two groups after treatment were improved,compared with before treatment,and the difference was statistically significant(P<0.05).And the change of the score in the observation group was relatively correct.The difference between the two groups was significant(P<0.05),and the difference of belching symptom treatment score between the two groups was significant(P<0.01).The total effective rate of the observation group was 96.67%,which was significantly higher than 76.67%of the control group(P<0.01).Conclusion Yiwei Changqi decoction can effectively relieve the clinical symptoms of patients with chronic atrophic gastritis,thus improving the quality of life,which further verifies the effectiveness and feasibility of“observing pathogenesis”and“treating according to disease”.