血清IL-32γ水平与严重骨质疏松症患者骨密度的相关性研究

Study on the correlation between serum interleukin-32γand bone mineral density in patients with severe Osteoporosis

目的探讨血清白细胞介素-32γ水平与严重骨质疏松症患者骨密度的相关性。方法收集290例因严重骨折而入院并在南充市中心医院就诊的受试者。同时收集1027名在体检中心进行体检的人群作为对照组,从病例组中进行了1∶1的年龄和性别匹配。结果在164名年龄和性别匹配的受试者中,骨折组的白细胞介素-32γ显著低于非骨折组(P=0.001)。严重骨质疏松组白细胞介素-32γ水平显著低于非严重骨质疏松组(P=0.002)。年龄和血清白细胞介素-32γ水平降低是骨质疏松症的独立危险因素(优势比[OR]=1.088,P=0.008,置信区间[CI]=[1.022~1.157];OR=0.840,P=0.037,CI=0.713~0.989)。结论骨折组血清白细胞介素-32γ水平明显低于非骨折组和严重骨质疏松组,而非严重骨质疏松组明显低于非骨折组。结果表明血清白细胞介素-32γ水平的降低可能是骨质疏松症的独立危险因素。

Objective To investigate the correlation between serum Interleukin-32γlevels and bone mineral density in patients with severeosteoporosis.Methods We enrolled 290 subjects who were admitted and operated at Nanchong Central Hospital due to major fractures.At the same time,we collected 1027 people undergoing physical examination at the physical examination center as a control group.We carried a 1∶1 matching with age and sex from the case group.Results Among 164 age-and sex-matched subjects,serum sodium level was significantly lower in the fracture group than that in the non-fracture group(P=0.001).Serum Interleukin-32γlevel was significantly lower in the severe osteoporosis group than that in the non-severe osteoporosis group(P=0.002).Age and decreased serum Interleukin-32γlevel were the independent risk factors of osteoporosis(odds ratio[OR]=1.088,P=0.008,confidence interval[CI]=[1.022-1.157];OR=0.840,P=0.037,CI=0.713-0.989).Conclusion The level of serum interleukin-32γin the fracture group was significantly lower than that in the non-fracture group and the severe osteoporosis group,while the non-severe osteoporosis group was significantly lower than the non-fracture group.based on our result,the decrease in serum Interleukin-32γlevel could be an independent risk factor for osteoporosis.