龟板调控BMSCs增殖、迁移和成骨分化及其抗骨质疏松症的研究进展

Research progress of plastrum testudinis in regulating BMSCs’proliferation,migration and osteogenic differentiation and its anti-osteoporosis

近年来,中医药在抗骨质疏松症方面显示出独特优势。龟板被证实可通过miRNA及其靶基因、信号通路及相关因子调控BMSCs功能,从而抗骨质疏松症。本文对龟板调控BMSCs增殖、迁移和成骨分化及其抗骨质疏松症的研究进展进行综述,发现龟板体外可通过调节BMP-4、VDR、RARα、Id1等表达调控BMSCs增殖;可上调HGF/c-met轴、SDF-1/CXCR4轴促进BMSCs迁移;可通过调节成骨相关因子、miRNAs和信号通路调控BMSCs成骨分化。此外,龟板体内可有效抗PMOP、GIOP和SOP。本文旨在为中医药防治骨质疏松症提供相关参考。

Recently,traditional Chinese medicine has shown unique advantages in anti-osteoporosis.Plastrum testudinis(PT)has been shown to affect the function of BMSCs through regulating osteoblast-related miRNAs’target genes,signaling pathways and related-factors,thereby achieving anti-osteoporosis effect.In this paper,we reviewed the effects of PT on the proliferation,migration,and osteogenic differentiation of BMSCs and its mechanism on anti-osteoporosis,providing references for anti-osteoporosis in traditional Chinese medicine.It have been found that PT can regulate BMSCs’proliferation through BMP-4,VDR,RARαand Id1 in vitro.PT can up-regulate the axis of HGF/c-met and SDF-1/CXCR4 to promote the migration of BMSCs.PT can regulate BMSCs’osteogenic differentiation through osteoblast-related factors,miRNAs and signaling pathways.In addition,PT can effectively resist PMOP,GIOP and SOP in vivo.This will provide references for anti-osteoporosis using traditional Chinese medicine.