盐地碱蓬膳食纤维对高脂血症大鼠的降血脂作用

Hypolipidemic Effects of Dietary Fiber from Suaeda sulsa in Hyperlipidemic Rats

探究盐地碱蓬膳食纤维对高脂血症大鼠的降血脂作用,56只雄性SD大鼠随机平分为7组:正常组、盐地碱蓬膳食纤维预防组、高脂模型组,阳性对照组,盐地碱蓬膳食纤维高、中、低浓度3个干预组。干预6周后,分别测定各组大鼠的体重、摄食量、脏器重量、附睾周脂重量、肝脏系数、动脉硬化指数及血清血脂水平。结果:与高脂模型组相比,干预组的体重、摄食量、心脏、肝脏、脾脏、肺脏、肾脏、附睾周脂重、肝脏系数、动脉硬化指数均有下降,其最大降幅分别为:26.21%、26.66%、27.01%、46.03%、35.71%、3.43%、22.69%、57.14%、39.92%、76.94%。血脂方面,干预组较高脂模型组的TC、TG、LDL-C值均降低,其最大降幅分别为:19.12%、87.20%、60.50%。较阳性组,高剂量组的LDL-C降低38.16%,HDL-C升高27.01%,存在显著性差异(p<0.05)。预防组与正常组比,脏器重量均有不同程度减少,血脂方面,预防组较正常组的TG、LDL-C值均降低,分别为:68.85%、31.64%,HDL-C升高12.88%。表明盐地碱蓬膳食纤维对高脂血症大鼠体重、摄食量、脏器重量、附睾周脂重、肝脏系数及动脉硬化指数具有预防及控制作用,并且对高血脂有降脂作用。

To explore the hypolipidemic effects of the dietary fiber from Suaeda salsa on rats with hyperlipidemia,56 male SD rats were randomly divided into 7 groups:normal group,Suaeda salsa dietary fiber prevention group,high-fat model group,positive control group,and three intervention groups with high,medium and low concentrations of dietary fiber in Suaeda salsa.After 6 weeks of intervention,the body weight,food intake,organ weight,periepididymal fat weight,liver coefficient,arteriosclerosis index and serum lipid levels of the rats in each group were measured.Results:Compared with the high-fat model group,the body weight,food intake,heart,liver,spleen,lung,kidney,periepididymal fat weight,liver coefficient,and arteriosclerosis index of the intervention group all decreased,with the largest decreases being 26.21%,26.66%,27.01%,46.03%,35.71%,3.43%,22.69%,57.14%,39.92%and 76.94%,respectively.In terms of blood lipids,the TC,TG,and LDL-C values of the higher-fat model group in the intervention group all decreased,with the largest decreases being 19.12%,87.20%,and 60.50%,respectively.Compared with the positive group,LDL-C decreased by 38.16%and HDL-C increased by 27.01%in the high-dose group(p<0.05).Compared with the normal group,the organ weights of the prevention group were reduced to different extents.The TG and LDL-C values of the prevention group(68.85%and 31.64%,respectively)were lower,whilst the HDL-C increased by 12.88%,compared with those of the normal group.These results indicated that the dietary fiber of Suaeda salsa had desirable effects on monitoring body weight,food intake,organ weight,perididymal fat weight,liver coefficient and arteriosclerosis index of hyperlipidemic rats,and exhibited a lipid-lowering effect on hyperlipidemia.