LIFR基因mRNA表达对乳腺癌患者预后的判断价值

Prognostic values of LIFR mRNA expression in breast cancer patients

目的探讨LIFR基因m RNA表达情况与乳腺癌患者预后的关系。方法通过Kaplan-Meier Plotter数据分析工具对截止2019年11月1日收录在GEO数据库中登记的乳腺癌组织中LIFR基因mRNA表达情况与患者总生存期及无复发生存期之间的关系进行分析。结果整体样本分析中,LIFR基因mRNA的高表达与乳腺癌患者更好的总生存时间(OS)(HR:0.7,95%Cl:0.57~0.87,P=0.001 2)和无复发生存率(RFS)(HR:0.7,95%CI:0.63~0.78,P=0.000 0)呈正相关;亚组分析中,OS方面,LIFR基因m RNA的高表达在Luminial B型亚组患者中与更好的OS呈正相关性(HR:0.66,95%CI:0.45~0.96,P=0.029),而在癌细胞病理分级Ⅰ级的亚组患者中与更差的OS呈正相关性(HR:7.57,95%CI:1.01~56.76,P=0.02),其余亚组分析中OS比较差异均无统计学意义(P>0.05);RFS方面,LIFR基因mRNA的高表达在Luminal A型、Luminal B型、Basal-like型三种亚型的患者群中与更好的RFS呈正相关,即Luminal A型(HR:0.69,95%CI:0.57~0.84,P=0.000 15)、Luminal B型(HR:0.68,95%CI:0.56~0.82,P=0.000 0)、Basal-like (HR:0.66,95%CI:0.52~0.85,P=0.001 4),但在Her-2阳性的亚组中,OS及RFS比较差异均无统计学意义(P>0.05)。结论 LIFR基因m RNA的高表达在乳腺癌患者整体人群预示着更好的RFS及OS,可作为乳腺癌患者预后的预测因子,但亚组分析中,这种预后指示作用可能有差别,这其中的内在机制仍需继续深入探究。

Objective To investigate the relationship between LIFR mRNA expression and prognosis of patients with breast cancer.Methods The Kaplan-Meier Plotter data analysis tool was used to analyze the relationship between the LIFR gene mRNA expression in breast cancer tissues registered in the GEO database until November 1,2019 and the overall survival(OS)and recurrence-free survival(RFS)of patients.Results In the overall sample analysis,high mRNA expression of LIFR gene were associated with better OS(HR:0.7,95%CI:0.57-0.87,P=0.0012)and RFS(HR:0.7,95%CI:0.63-0.78,P=0.0000).In the subgroup analysis,in terms of OS,the high expression of LIFR gene mRNA was positively correlated with better OS in Luminial B subgroup patients(HR:0.66,95%CI:0.45-0.96,P=0.029),and the subgroup of patients with cancer cell pathological gradeⅠwas positively correlated with worse OS(HR:7.57,95%CI:1.01-56.76,P=0.02).There was no statistically significant difference in OS among the other subgroups(P>0.05).In terms of RFS,the high expression of LIFR gene mRNA in the three subtypes of Luminal A,Luminal B,and Basal-like is positively correlated with better RFS:Luminal A(HR:0.69,95%CI:0.57-0.84,P=0.00015),Luminal B type(HR:0.68,95%CI:0.56-0.82,P=0.0000),Basal-like(HR:0.66,95%CI:0.52-0.85,P=0.0014);but in the Her-2 positive subgroup,there was no statistically significant difference in OS and RFS(P>0.05).Conclusion The high expression of LIFR gene mRNA predicts better RFS and OS in the whole population of breast cancer patients,and can be used as a predictor of prognosis in breast cancer patients.However,in subgroup analysis,this prognostic results may be different,thus more studies are needed to explore the mechanism.