3-氟吡啶-2-甲醇的合成

Synthesis of(3-Fluoropyridin-2-yl)methanol

以价格低廉的喹啉酸为起始原料,通过酸酐化、酯化、氨化、氨基氟化、酯基还原等步骤合成目标化合物3-氟吡啶-2-甲醇,通过1HNMR、13CNMR和19FNMR对其结构进行表征。该方法成本低、工艺简单、收率高、质量好,具有较高的工业化应用价值,是一种全新的3-氟吡啶-2-甲醇的合成路线。

Using cheap quinolinic acid as a raw material,we synthesized the target compound(3-fluoropyridin-2-yl)methanol by anhydridization,esterification,ammoniation,amino fluorination,and ester reduction.Moreover,we characterized the structure by 1HNMR,13CNMR,and 19FNMR.The novel synthetic route of(3-fluoropyridin-2-yl)methanol has high industrial value with low cost,simple process,high yield,and good quality.