非编码RNA在干燥综合征中的研究进展

Research progress of non-coding RNA in sjögren′s syndrome

干燥综合征(SS)是一种慢性自身免疫性疾病,以外分泌腺淋巴细胞浸润为主要特点,以口干、眼干为主要临床表现。SS发病机制尚未明确,病因包括遗传、病毒感染以及环境因素等,造成机体免疫功能失衡,产生多种自身抗体及细胞因子造成组织损伤。近年来非编码RNA(ncRNA)在疾病调控中所发挥的作用受到重视,研究显示SS患者存在ncRNA表达异常,在SS免疫炎症反应过程中发挥着重要作用。本文综述ncRNA在干燥综合征中的相关研究进展。

Sjögren′s syndrome(SS)is a chronic autoimmune disease characterized by exocrine lymphocyte infiltration.The main clinical manifestations are dry mouth and dry eye.The pathogenesis of SS remains unclear.The causes include genetic,viral infections and environmental factors,resulting in imbalance of immune function and a variety of autoantibodies and cytokines causing tissue damage.In recent years,the role of non-coding RNA(ncRNA)in disease regulation is valued.Studies have shown that SS patients have abnormal expression of ncRNA which plays an important role in the process of SS immune inflammatory reaction.This article reviews the research progress of ncRNA in Sjögren′s syndrome.