纯钛-骨补碎-生物复合涂层的研究

Study on Pure Titanium-Drynariae and Biological Composite Coating

钛及钛合金在骨植入材料领域应用广泛,但也面临不能诱导骨生长且无抗菌活性等一系列问题,在钛合金表面超声微弧氧化膜,再用植酸偶联剂/骨补碎提取液制备生物活性涂层复合材料,改善钛合金无生物活性的问题。方法以浓度依次提高的骨碎补为实验组,经过植酸等手段处理的涂层作为对照组,利用能谱、接触角,SEM等手段研究载药涂层的耐蚀性,生物活性以及与适应性等涂层性能。结果当骨补碎浓度为50 g/L时涂层表面变得平整光滑,涂层有较好的润湿性,经过模拟体液浸泡后发现涂层表面长出大量的类羟基磷灰石,证明制备的新型复合涂层材料综合性能优良。结论钛合金UMAO-植酸/骨补碎-生物复合涂层具有较好的生物活性。

Objective Titanium and titanium alloys are widely used in the field of bone implant materials,but they also face a series of problems such as inability to induce bone growth and no antibacterial activity.Ultrasonic micro-arc oxidation film on the surface of titanium alloy,and then use phytic acid coupling agent and bone repair crushed extracts are used to prepare bioactive coating composite materials,which improves the problem of titanium alloys having no bioactivity.Methods The phytic acid-treated coating was used as the control group,and the bone concentration of different concentrations of bone was used as the experimental group.Elements,SBF soaked to produce coating properties such as bone-like apatite.Results When the drynariae concentration was 50g/L,the coating surface became smooth and smooth,the wettability was good,a large amount of HA was generated after simulated body fluid immersion,and the prepared composite membrane had the best comprehensive performance.Conclusion The biological activity of titanium alloy UMAO-phytic acid/drynariae extract solution-biocomposite coating is significantly improved.