摘要
钛及钛合金在骨植入材料领域应用广泛,但也面临不能诱导骨生长且无抗菌活性等一系列问题,在钛合金表面超声微弧氧化膜,再用植酸偶联剂/骨补碎提取液制备生物活性涂层复合材料,改善钛合金无生物活性的问题。方法以浓度依次提高的骨碎补为实验组,经过植酸等手段处理的涂层作为对照组,利用能谱、接触角,SEM等手段研究载药涂层的耐蚀性,生物活性以及与适应性等涂层性能。结果当骨补碎浓度为50 g/L时涂层表面变得平整光滑,涂层有较好的润湿性,经过模拟体液浸泡后发现涂层表面长出大量的类羟基磷灰石,证明制备的新型复合涂层材料综合性能优良。结论钛合金UMAO-植酸/骨补碎-生物复合涂层具有较好的生物活性。
Objective Titanium and titanium alloys are widely used in the field of bone implant materials,but they also face a series of problems such as inability to induce bone growth and no antibacterial activity.Ultrasonic micro-arc oxidation film on the surface of titanium alloy,and then use phytic acid coupling agent and bone repair crushed extracts are used to prepare bioactive coating composite materials,which improves the problem of titanium alloys having no bioactivity.Methods The phytic acid-treated coating was used as the control group,and the bone concentration of different concentrations of bone was used as the experimental group.Elements,SBF soaked to produce coating properties such as bone-like apatite.Results When the drynariae concentration was 50g/L,the coating surface became smooth and smooth,the wettability was good,a large amount of HA was generated after simulated body fluid immersion,and the prepared composite membrane had the best comprehensive performance.Conclusion The biological activity of titanium alloy UMAO-phytic acid/drynariae extract solution-biocomposite coating is significantly improved.
作者
王树琪
李玉娇
耿建欣
鞠建一
单思涵
刘重阳
牟立婷
WANG Shu-qi;LI Yu-jiao;GENG Jian-xin;JU Jian-yi;SHAN Si-han;LIU Chong-yang;MU Li-ting(School of Pharmacy, Jiamusi University, Jiamusi Heilongjiang 154007,China;School of Materials Science and Engineering, Jiamusi University, Jiamusi Heilongjiang 154007,China)
出处
《佳木斯大学学报(自然科学版)》
CAS
2020年第6期88-90,共3页
Journal of Jiamusi University:Natural Science Edition
基金
2020年佳木斯大学大学生创新创业训练计划项目(XJYF2020-7)。
关键词
钛合金
微弧氧化
骨补碎
植酸
生物活性
titanium alloy
micro-arc oxidation
drynariae
phytic acid
biological activity