羟氯喹治疗妊娠期血液高凝状态对孕妇视网膜功能的影响

Effect of treatment of hypercoagulable state during pregnancy by hydroxychloroquine on retinal function of pregnant women

目的分析羟氯喹治疗妊娠期血液高凝状态对孕妇视网膜功能的影响。方法选取2019年1-12月在吉林省妇幼保健院产科门诊服用硫酸羟氯喹片的206例(412眼)妊娠期血液高凝状态孕妇,均进行眼部检查,用药后每3个月复查1次。比较不同用药时间对血液高凝状态孕妇视网膜的影响率,不同用药时间的血液高凝状态孕妇视野平均缺损、最佳矫正视力、黄斑区容积和视网膜厚度。结果不同用药时间对血液高凝状态孕妇视网膜的影响率比较差异无统计学意义(P>0.05)。不同用药时间的血液高凝状态孕妇视野平均缺损、最佳矫正视力、黄斑区容积和视网膜厚度比较差异均无统计学意义(均P>0.05)。结论孕期服用安全剂量的羟氯喹对孕妇视网膜是安全的。

Objective To analyze the effect of treatment of hypercoagulable state during pregnancy by hydroxychloroquine on retinal function of pregnant women.Methods From January to December in 2019,206 pregnant women(412 eyes)with hypercoagulable state treated by oral administration of hydroxychloroquine sulfate tablets in Outpatient of Obstetrics in Jilin Provincial Maternal and Child Health Care Hospital were selected,examination of eyes was performed,after treatment,reexamination was performed every three months.The influence rates on retina,the mean visual field defect,the best corrected visual acuity,macular region volume,and retinal thickness of pregnant women with different medication time were compared.Results There was no statistically significant difference in the influence rates on retina among pregnant women with different medication time(P>0.05).There was no statistically significant difference in the mean visual field defect,the best corrected visual acuity,macular region volume,and retinal thickness among pregnant women with different medication time(P>0.05).Conclusion Safe dose of hydroxychloroquine during pregnancy is safe for retina of pregnant women.