胃癌肝转移的综合治疗进展

Advance in comprehensive treatment of liver metastasis of gastric cancer

胃癌是临床上最常见的消化系统恶性肿瘤之一,具有异质性强、进展快和预后差等特点。胃癌肝转移是造成晚期胃癌死亡最主要的原因。目前,临床上胃癌的治疗方式主要包括系统治疗(全身化疗、靶向治疗、免疫治疗)、手术切除、介入治疗及放疗等,但治疗效果均欠佳,胃癌肝转移更是缺乏规范化的治疗策略。目前,多学科综合治疗模式在恶性肿瘤诊疗中广泛应用,取得了很好的效果。中国胃肠外科专家组根据胃癌肝转移的临床特点及手术可及性,将其分为3大临床类型,分别为可切除型、潜在可切除型及不可切除型。各种临床类型的患者需多学科综合治疗协作组专家讨论后制定出个体化的治疗方案。

Gastric cancer is one of the most common malignant tumors of digestive system,which has the characteristics of strong heterogeneity,rapid progress and poor prognosis.Liver metastasis of gastric cancer is the main cause of death of advanced gastric cancer.At present,the clinical treatment of gastric cancer mainly includes systematic treatment(systemic chemotherapy,targeted treatment,immunotherapy),surgical resection,interventional treatment and radiotherapy,but the therapeutic effects are not good,and liver metastasis of gastric cancer is lack of standardized treatment strategy.At present,the multi-disciplinary comprehensive treatment mode has been widely used in the diagnosis and treatment of malignant tumors,and has achieved good results.According to the clinical characteristics and surgical accessibility of liver metastasis of gastric cancer,the Chinese Gastrointestinal Surgery Expert Group divides it into three clinical types:resectable type,potential resectable type and non-resectable type.All kinds of clinical types of patients need multidisciplinary comprehensive treatment cooperation group experts to discuss and formulate individualized treatment plan.