皮肤鳞状细胞癌表观遗传学发病机制

Epigenetic pathogenesis of cutaneous squamous cell carcinoma

皮肤鳞状细胞癌(CSCC)是起源于表皮及其附属器角质形成细胞的一种恶性肿瘤,病因及发病机制复杂且尚不明确。CSCC的发病率在全球范围内总体上呈增长趋势,使得对其发病机制的研究日渐增多。表观遗传不改变基因组序列,通过DNA甲基化、组蛋白修饰、非编码RNA、染色质重塑等方式调控基因表达。其可逆、稳定的遗传特征将为CSCC发病机制研究提供新的思路。

Cutaneous squamous cell carcinoma(CSCC)is a kind of malignant tumor originated from keratinocytes within the epidermis and its appendages.Its etiology and pathogenesis are complex and unclear.The incidence of CSCC is increasing in the whole world,which makes the research on its pathogenesis increasing day by day.Epigenetics does not change genome sequence,but regulates gene expression by DNA methylation,histone modification,noncoding RNA,chromatin remodeling and so on.Its reversible and stable genetic characteristics will provide a new idea for the study of pathogenesis of CSCC.