组织追踪MR技术评价正常人左室形变功能的临床研究

Tissue tracking magnetic resonance for evaluation of left ventricular global myocardial deformation in healthy subjects

目的:采用心脏磁共振(cardiac magnetic resonance,CMR)电影序列的组织追踪技术探讨正常人左室应变。方法:随机入组2018年于复旦大学附属中山医院行CMR检查的健康志愿者39例,将影像学Dicom资料存盘后,应用CVI软件的组织追踪模块分析CMR电影序列图像,比较左室心肌形变指标基底段、中间段与心尖段的差别;内膜下与外膜下的差别;性别间、年龄分组间的差别。结果:39例健康志愿者左室内膜下、外膜下及整体心肌应变自基底段至心尖段递增;自心内膜下至心外膜下左室心肌应变递减,差异有统计学意义(P<0.05);性别对左室应变无明显影响。结论:组织追踪MR可定量分析左室整体、节段与内膜下、外膜下心肌形变功能,为临床评价心脏功能提供新的依据。

Objective:To explore the left ventricular(LV)myocardial deformation function in healthy subjects using cardiac magnetic resonance(CMR)tissue tracking imaging derived LV deformation parameters.Methods:Thirty nine healthy volunteers who underwent CMR imaging in Zhongshan Hospital,Fudan University in 2018 were randomly enrolled.The LV myocardial deformation was evaluated using tissue tracking analysis module of CVI analyzing software based on cine MR sequences.Comparation of LV deformation was done according to level(LV basal,mid and apical planes),layer(subendocardial and subepicardial myocardium),gender,and age groups.Results:LV myocardial systolic deformation function in normal subjects increased from basal plane to apical plane.LV myocardial systolic deformation function decreased from subendocardial myocardium to subepicardial myocardium.Gender had little influence on the LV deformation function.Conclusion:MR-based LV global deformation parameters could be a useful method to assess LV myocardial deformation function.