青斑样血管病发病机制

Pathogenesis livedoid vasculopathy

青斑样血管病的病因与发病机制尚不明确,结合皮损组织病理学真皮血管管腔内血栓形成、内皮细胞增生的特点及辅助检查的多种凝血功能异常发现,目前倾向于该病是一种血栓闭塞性脉管疾病。血液高凝易栓因素在疾病的发生发展过程中起到主要作用,但其发病机制可能相对较为复杂,涉及多种因素,并非单一继发于凝血功能的紊乱,炎症、代谢、免疫因素也可能与之产生交联,促进血液的高凝易栓状态发挥作用,从而参与青斑样血管病的发病。

The etiology and pathogenesis of livedoid vasculopathy still remains unknown.On the basis of its endothelial cell proliferation,intraluminal thrombosis in histology manifestations and multiple coagulation abnormalities in laboratory examinations,livedoid vasculopathy is currently considered as one kind of thrombo-occlusive vasculopathy of cutaneous blood vessels,which hypercoagulability plays a major role in the onset and development of disease process.However,its pathogenesis may be complicated,involving a variety of factors.Besides secondary to hypercoagulability and thrombosis,inflammatory,metabolic and immune factors may also be of cross-linking and participate in its pathogenesis by promoting hypercoagulability.