25(OH)D3缺乏与腹膜透析相关性腹膜炎发生风险的相关性研究

Correlation Study Between 25(OH)D3 Deficiency and Risk of Peritonitis Associated with Peritoneal Dialysis

目的探讨血25-羟胆钙化醇D3[25(OH)D3]缺乏与腹膜透析相关性腹膜炎(PDRP)发生风险的关系。方法选取2017年1月至2019年6月在我院行腹膜透析患者180例,比较分析发生与未发生PDRP患者的临床资料。结果180例患者中,56例发生PDRP(PDRP组),发生率31.11%,124例患者未发生PDRP(对照组)。PDRP组年龄、透析时间和初始透析年龄分别为(65.39±8.39)岁、(55.40±8.28)月和(60.02±9.11)岁,明显高于对照组(P<0.05);PDRP组尿素氮(30.02±10.11)mmol/L,铁蛋白(210.20±89.28)μg/L和CRP(66.60±34.40)mg/L高于对照组,差异有统计学意义(P<0.05),而25(OH)D3(13.38±3.29)ng/L,白蛋白(25.43±8.29)g/L、血红蛋白(85.72±10.11)g/L低于对照组,差异有统计学意义((P<0.05)。Logistic回归分别结果显示:年龄、透析时间、25(OH)D3是PDRP发生的影响因素(P<0.05)。结论25(OH)D3缺乏是腹膜透析患者发生PDRP的影响因素,值得临床注意。

Objective To investigate the relationship between the lack of blood 25-hydroxycholecalciferol D3[25(OH)D3]and the risk of peritoneal dialysis-related peritonitis(PDRP).Methods From January 2017 to June 2019,a total of 180 patients who underwent peritoneal dialysis in our hospital were selected.Clinical data of patients with and without PDRP were compared and analyzed.Results Among 180 patients,56 patients developed PDRP(PDRP group)with 31.11%incidence,and 124 patients did not develop PDRP(control group).The age,dialysis time and initial dialysis age of PDRP group were(65.39±8.39)years,(55.40±8.28)months and(60.02±9.11)years,respectively,which were significantly higher than those in control group(P<0.05).The PDRP group s urea nitrogen(30.02±10.11)mmol/L,ferritin(210.20±89.28)μg/L and CRP(66.60±34.40)mg/L were higher than those of control group with statistically significant difference(P<0.05).While 25(OH)D3(13.38±3.29)ng/L,albumin(25.43±8.29)g/L,hemoglobin(85.72±10.11)g/L were lower than those of control groupwith statistically significant difference(P<0.05).The logistic regression results showed that age,dialysis timeand 25(OH)D3 were influencing factors of PDRP(P<0.05).Conclusion The lack of 25(OH)D3 is an influencing factor for PDRP in peritoneal dialysis patients,which deserves clinical attention.