SIRT1功能及其对卵泡发育和卵母细胞成熟的调控作用

The Function of SIRT1 and Its Role in Regulating Follicular Development and Oocyte Maturation

沉默信息调节因子1(silent information regulator1,SIRT1)是NAD+依赖的去乙酰化酶,通过使底物发生去乙酰化而参与细胞众多生理功能的调节,在糖脂代谢、衰老、细胞凋亡、氧化应激等过程中发挥了重要作用。另外,众多研究表明,SIRT1是调控动物卵巢老化、卵泡发育和卵母细胞成熟的重要因子,SIRT1表达下降或活性改变将导致卵母细胞老化,降低动物的繁殖力。为了充分理解SIRT1功能,并通过调控SIRT1活性而延缓卵巢和卵母细胞老化,从而提高动物繁殖力,简述了SIRT1的激活及其参与细胞内调控的生物过程,并从能量代谢、抗氧化胁迫、染色质重塑的角度讨论了SIRT1的主要功能,重点阐述了SIRT1对动物卵泡发育和卵母细胞成熟的调控作用。

Silent information regulator the factor 1 SIRT1(SIRT1),is NAD+dependent enzymes with deacetylase activity,which participates in the regulation of many physiological functions of cells through substrate deacetylation,playing important roles in the process of glycolipid metabolism,aging,apoptosis,oxidative stress and so on.In addition,some studies have shown that SIRT1 is an important factor in the regulation of ovarian aging,follicular development and oocyte maturation.Moreover,the decrease of SIRT1 expression or the change of SIRT1 activity will lead to the aging of oocytes and the reduction of animal fertility.Therefore,to fully understand the function of SIRT1,and delay the aging of ovary and oocyte by regulating SIRT1 activity,thereby improving animal fertility,this paper describes the activation of SIRT1 and its biological processes involved in intracellular regulation,and discusses the main functions of SIRT1 from the perspective of energy metabolism,antioxidant stress and chromatin remodeling,highlights the regulatory roles of SIRT1 in animal follicular development and oocyte maturation.