念珠菌与宿主相互作用的研究进展

Research advance of the interaction between Candida and the host

念珠菌是一类最常见的人类机会性致病真菌,可导致致命的侵袭性念珠菌病,严重威胁人类生命与健康。深入了解念珠菌与宿主之间的相互作用,有助于为诊断、预防和治疗念珠菌病提供新的理论策略。本文综述了念珠菌与宿主相互作用的最新研究进展,概括了念珠菌的致病机制和宿主的免疫应答两方面内容,重点分析了念珠菌的形态转换、分泌型蛋白、模式识别受体以及介导的固有免疫和适应性免疫应答,并对未来念珠菌与宿主的研究方向进行了展望。

Candida,one of the most common human opportunistic pathogens,can cause deadly invasive candidiasis and seriously threaten human life and health.An in-depth understanding of the interaction between Candida and the host will help providing new theoretical strategies for the diagnosis,prevention and treatment of candidiasis.In this review,we detailed the latest research progress on the host-pathogen interaction,and summarized the pathogenic mechanism of Candida and the host’s immune response.We focused on morphological transformation,secreted proteins,pattern recognition receptors,and mediated innate and adaptive immune responses of Candida.Future research directions for host-pathogen interaction were also prospected.