致病性念珠菌对常见抗真菌药物的耐药性研究进展

Research progress on resistance of pathogenic Candida species to common antifungal drugs

近年来,致病性念珠菌感染引起的侵袭性念珠菌病患者人数逐年增多。白念珠菌仍是引起感染的主要致病菌,但是由非白念念珠菌引起的感染比例显著升高。致病性念珠菌对常见抗真菌药物的耐药现象呈上升趋势,这是导致临床治疗其所致的侵袭性感染失败的重要原因之一。本文就致病性念珠菌耐药性的流行病学以及其耐药机制方面的研究进展进行了介绍。

In recent years,the number of patients suffering from invasive candidiasis caused by pathogenic Candida species has increased.Although Candida albicans remains the most common pathogen,non-albicans Candida infections have increased significantly.The resistance of pathogenic Candida species to common antifungal drugs trends to rise,causing the failure of clinical treatment of infection.In this review,the research progress on the epidemiology of drug-resistance and resistant mechanisms of pathogenic Candida species are described.