血管周围间隙在脑小血管病中的研究进展

Progress of Perivascular Spaces in Cerebral Small Vessel Disease

血管周围间隙(perivascular spaces,PVS)是脑小血管周围充满液体的潜在腔隙。扩大的血管周围间隙(enlarged perivascular spaces,e PVS)已成为脑小血管病(cerebral small vessel diseases,CSVD)公认的影像标志物之一。PVS的量化依赖于MRI,难点在于e PVS与腔隙灶的鉴别。PVS被证明与年龄、高血压、其他CSVD影像学标志物、认知功能损害、全身性炎症相关,但仍缺乏较为长期的、针对不同人群的队列研究。研究e PVS与CSVD病程的关系,有助于临床上对CSVD的早期发现和风险预测。

Perivascular spaces(PVS)are potential spaces filled with fluid around cerebral small vessels.Enlarged perivascular spaces(ePVS)have become one of the recognized imaging markers of cerebral small vessel disease(CSVD).The quantification of PVS depends on MRI,and the difficulty lies in the differentiation between ePVS and lacuna.Previous studies have shown that PVS is associated with age,hypertension,other CSVD imaging markers,cognitive impairment,and systematic inflammation.However,the long-term cohort studies in different populations still lack.To study the relationship between ePVS and the course of CSVD is helpful for early detection and risk prediction of CSVD.