早期应用甲强龙治疗肺炎支原体感染后大叶性肺炎的疗效观察

Early application of methylprednisolone in the treatment of lobar pneumonia caused by Mycoplasma pneumoniae

目的分析早期应用甲强龙治疗肺炎支原体感染后大叶性肺炎的临床效果。方法80例肺炎支原体感染后大叶性肺炎患儿,按照入院先后顺序分为对比组和研究组,各40例。对比组患儿采用阿奇霉素治疗,研究组患儿采用甲强龙治疗。对比两组患儿治疗效果。结果研究组热退时间(3.58±1.49)d、咳嗽消失时间(4.69±2.05)d、肺部阴影与胸腔积液消失时间(5.31±2.09)d、C反应蛋白(CRP)恢复时间(4.66±3.17)d均明显短于对比组的(4.83±1.62)、(6.33±3.29)、(6.87±3.56)、(6.43±3.52)d,差异有统计学意义(P<0.05)。研究组不良反应发生率12.50%低于对比组的32.50%,差异有统计学意义(P<0.05)。研究组治疗总有效率95.00%明显高于对比组的75.00%,差异有统计学意义(P<0.05)。研究组用力肺活量(FVC)、第1秒用力呼气容积(FEV1)及呼气峰流速(PEF)均明显优于对比组,差异有统计学意义(P<0.05)。结论临床采用甲强龙治疗肺炎支原体感染后大叶性肺炎患儿,其早期效果显著,患儿用药后临床症状消失时间较短,故值得在临床中广泛应用。

Objective To analyze the clinical effect of early application of methylprednisolone in the treatment of lobar pneumonia caused by Mycoplasma pneumoniae.Methods A total of 80 children with lobar pneumonia caused by Mycoplasma pneumoniae were divided into control group and research group according to admission order,with 40 cases in each group.The control group was treated with azithromycin,and the research group was treated with methylprednisolone.The therapeutic effect of the two groups was compared.Results The fever lasting time(3.58±1.49)d,cough disappearance time(4.69±2.05)d,disappearance time of lung shadow and pleural effusion(5.31±2.09)d,C reactive protein(CRP)recovery time(4.66±3.17)d of the research group were obviously shorter than(4.83±1.62),(6.33±3.29),(6.87±3.56)and(6.43±3.52)d of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 12.50%of the research group was lower than 32.50%of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment 95.00%of the research group was obviously higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).The forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)and peak expiratory flow rate(PEF)of the research group were obviously better than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Methylprednisolone has a significant early effect in the treatment of Mycoplasma pneumoniae caused by lobar pneumonia,and the clinical symptoms disappear in a short period of time after treatment,so it is worthy of widespread clinical application.