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阿奇霉素、阿莫西林、克洛己新干混悬剂治疗儿童呼吸道感染药物经济学比较 被引量:1

Comparison of pharmacoeconomics of azithromycin,amoxicillin and cefaclor and bromhexine hydrochloride for suspension in treatment of children with respiratory tract infection
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摘要 目的观察分析阿奇霉素、阿莫西林、克洛己新干混悬剂治疗儿童呼吸道感染药物经济学。方法选取105例呼吸道感染患儿作为研究对象,采取随机分组的方式分为A组、B组和C组,各35例。A组采取阿奇霉素治疗,B组采取阿莫西林治疗,C组采取克洛己新干混悬剂治疗。比较三组患儿临床疗效,并分析三组患儿不良反应发生情况和成本-效果比。结果治疗后,A组治疗总有效率为91.43%,B组治疗总有效率为85.71%,C组治疗总有效率为94.29%,三组患儿治疗总有效率比较,差异无统计学意义(P>0.05)。三组患儿均未出现严重不良反应,部分患儿出现轻微肠胃道异常,如恶心、腹痛、腹泻等,均在治疗结束后均自行消失。C组患儿成本效果比0.700显著低于A组的0.931的和B组的0.817。结论克洛己新干混悬剂治疗儿童呼吸道感染效果好,安全有效,经济合理,值得临床应用。 Objective To observe and analyze the pharmacoeconomics of azithromycin,amoxicillin and cefaclor and bromhexine hydrochloride for suspension in treatment of children with respiratory tract infection.Methods A total of 105 children with respiratory tract infection as study subjects were randomly divided into group A,group B and group C,with 35 cases in each group.Group A was treated with azithromycin,group B was treated with amoxicillin,and group C was treated with cefaclor and bromhexine hydrochloride for suspension.The clinical efficacy of the three groups was compared,and the occurrence of adverse reactions and cost-effectiveness ratio were analyzed.Results After treatment,the total effective rate of treatment of group A was 91.43%,which was 85.71%of group B and 94.29%of group C.There was no statistically significant difference in total effective rate among three groups(P>0.05).There were no serious adverse reactions in all three groups.Some children had slight gastrointestinal abnormalities,such as nausea,abdominal pain,diarrhea,etc.,which all disappeared after treatment.The cost-effectiveness ratio 0.700 of group C was significantly lower than 0.931 of group A and 0.817 of group B.Conclusion Cefaclor and bromhexine hydrochloride for suspension is safe and effective,economical and reasonable in the treatment of children with respiratory tract infection,thus it is worth applying in the clinic.
作者 徐东晖 XU Dong-hui(Department of Pediatrics,People’s Hospital of Binhai County,Yancheng 224500,China)
出处 《中国现代药物应用》 2020年第24期112-113,共2页 Chinese Journal of Modern Drug Application
关键词 阿奇霉素 阿莫西林 克洛己新干混悬剂 儿童呼吸道感染 Azithromycin Amoxicillin Cefaclor and bromhexine hydrochloride for suspension Respiratory tract infection in children
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