前列地尔治疗老年失代偿期乙型肝炎肝硬化的疗效分析

Efficacy of alprostadil in the treatment of elderly patients with decompensated hepatitis B cirrhosis

目的分析老年失代偿期乙型肝炎肝硬化患者采用前列地尔治疗的临床效果。方法82例老年失代偿期乙型肝炎肝硬化患者,根据治疗方案不同分为对照组与观察组,各41例。对照组患者采取基础治疗,观察组患者在对照组基础上配合前列地尔治疗。比较两组患者腹腔积液深度、腹围、24 h尿量、血清肿瘤坏死因子-α(TNF-α)、转化生长因子β1(TGF-β1)水平、肝功能分级(Child-Pugh)积分、肝肾功能指标水平。结果治疗后,观察组腹腔积液深度、腹围、24 h尿量分别为(2.45±1.20)cm、(72.20±20.03)cm、(1262.50±333.30)ml,均优于对照组的(4.60±1.25)cm、(85.20±20.50)cm、(853.02±245.50)ml,差异有统计学意义(P<0.05)。治疗后,观察组TNF-α、TGF-β1水平及Child-Pugh积分均优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组白蛋白(ALB)、丙氨酸氨基转移酶(ALT)、血肌酐(SCr)、尿素氮(BUN)、凝血酶原活动度(PTA)水平均优于对照组,差异有统计学意义(P<0.05)。结论保肝等常规基础治疗的同时配合前列地尔治疗老年失代偿期乙型肝炎肝硬化可以促进患者临床症状以及肝肾功能等改善,治疗效果获得认可。

Objective To analyze the clinical effect of alprostadil in the treatment of elderly patients with decompensated hepatitis B cirrhosis.Methods A total of 82 elderly patients with decompensated hepatitis B cirrhosis were divided into control group and observation group according to different treatment regimens,with 41 cases in each group.Patients in the control group received basic treatments,and patients in the observation group were treated with alprostadil based on the control group.The depth of ascites,abdominal circumference,24-h urine volume,serum tumor necrosis factor-α(TNF-α),transforming growth factor-β1(TGF-β1),Child-Pugh classification of liver function,and liver and kidney function indexes were compared between the two groups.Results After treatment,the depth of ascites,abdominal circumference and 24-h urine volume of the observation group were(2.45±1.20)cm,(72.20±20.03)cm and(1262.50±333.30)ml,which were all better than(4.60±1.25)cm,(85.20±20.50),(85.20±20.50)cm and(853.02±245.50)ml of the control group,and the difference was statistically significant(P<0.05).After treatment,TNF-α,TGF-β1 and Child-Pugh integral of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the albumin(ALB),alanine aminotransferase(ALT),serum creatinine(SCR),blood urea nitrogen(BUN),prothrombin activity(PTA)of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Application of alprostadil on the basis of basic therapy of liver protection has affirmative effect for elderly patients with decompensated hepatitis B cirrhosis,and can promote the improvement of clinical symptoms and liver and kidney function.