振腹疗法联合活血解毒方干预原发性干燥综合征的疗效观察

Randomized Controlled Study on the Intervention of Zhenfu Therapy Combined with Huoxue Jiedu Decoction on Primary Sjogren′s Syndrome

目的:探究振腹疗法联合活血解毒汤治疗原发性干燥综合征的临床疗效。方法:选取2017年1月至2018年6月北京中医药大学东方医院收治的原发性干燥综合征患者60例作为研究对象,借助SAS软件区组随机分为对照组和观察组,每组30例。对照组给予活血解毒汤配方颗粒口服治疗,观察组予活血解毒汤联合振腹疗法治疗,干预2个月。治疗结束后,留取患者血液样本进行安全性及疗效指标检测,并在治疗前后分别进行中医证候评分、欧洲抗风湿病联盟SS患者汇报指数(ESSPRI)评分、疲劳量表(FSS、MFI-20)等量表评测。结果:对照组及观察组总有效率分别为78.9%和85.7%(P>0.05),2组患者治疗后中医证候积分、ESSPRI干燥评分、ESSPRI总分、FSS评分、MFI-20评分均显著改善(P<0.01及P<0.05);观察组在中医证候积分总分、疲劳单项积分、便秘单项积分、肌肤干燥单项积分、疼痛单项积分、ESSPRI疲劳评分、ESSPRI疼痛评分、ESSPRI总分、FSS评分、MFI-20评分方面,改善均优于对照组(P<0.05)。结论:活血解毒方单用及联合振腹疗法均可有效的改善原发性干燥综合征患者干燥、疲劳等症状,振腹疗法联合活血解毒方优于单用中药治疗。

Objective:To explore the clinical effect of Zhenfu therapy combined with Huoxue Jiedu Decoction in the treatment of primary Sjogren′s syndrome.Methods:A total of 60 patients with primary Sjogren′s syndrome were selected as the research objects and were randomly divided into a control group and an experimental group by SAS software.The control group was treated with Huoxue Jiedu Decoction Granule orally.The observation group was treated with Huoxue Jiedu Decoction combined with Zhenfu Therapy.The intervening period was 2 months.After the treatment,blood samples were collected for safety and efficacy evaluation,and TCM syndromes score,ESSPRI score and fatigue scale(FSS,MFI-20)etc.were evaluated before and after treatment.Results:The total effective rate of the control group and the observation group were 78.9%and 85.7%(P>0.05),the TCM syndrome score,dry score in ESSPRI,ESSPRI total score,FSS score and MFI-20 score of the 2 groups were significantly improved after treatment(P<0.01 and P<0.05);in the observation group,the total TCM syndrome score,fatigue score,constipation score,skin dryness score,pain score,fatigue score in ESSPRI,pain score in ESSPRI,ESSPRI total score,FSS score and MFI-20 score were better than those in the control group(P<0.05).Conclusion:Huoxue Jiedu Decoction combined with Zhenfu Therapy can effectively improve the symptoms of dryness and fatigue in patients with primary Sjogren′s syndrome,and Zhenfu Therapy combined with Huoxue Jiedu Decoction is better than traditional Chinese medicine alone.