特比萘芬在皮下及深部真菌感染中的临床应用

Clinical application of terbinafine in the treatment of subcutaneous and deep mycosis

特比萘芬丙烯胺类抗真菌药物,对丝状真菌、双相真菌及酵母菌具有广谱抗真菌活性。除了在皮肤癣菌感染中用作一线治疗用药,特比萘芬在皮肤皮下及深部真菌感染中,也有较为广泛的临床应用,是一种安全有效的治疗药物。

Terbinafine is an active allylamine antifungal agent with a mechanism of inhibiting squalene epoxidase in the fungal cell membrane.Its spectrum of in vitro fungicidal activity includes a broad range of dermatophyte,filamentous,dimorphic fungi,and some yeast species.Terbinafine had been widely used as the first-line treatment for superficial dermatophyte infection.In nearly two decades,terbinafine also had been proved to be highly effective and safe for a variety of subcutaneous and deep fungal infections,either in monotherapy or in combination therapy.