急性冠状动脉综合征患者血浆miR-375水平与预后的关系

Correlation between plasma microRNA-375 level and prognosis in patients with acute coronary syndrome

目的探讨急性冠状动脉综合征(ACS)患者血浆微小核糖核酸(mi R)-375水平与预后的关系。方法选取2016年3月至2017年4月在昆明医科大学第一附属医院接受经皮冠状动脉介入治疗(PCI)的206例ACS患者作为研究对象。采用实时荧光定量聚合酶链反应(PCR)法检测ACS患者血浆mi R-375水平,分析其与患者预后的关系。结果 PCI术后预后不良组血浆miR-375水平高于预后良好组,差异有统计学意义(P<0.05)。低miR-375组平均生存时间高于高miR-375组,差异有显著统计学意义(P<0.001)。Cox多因素分析结果显示,ACS家族史和miR-375是ACS预后的独立危险因素(P<0.05)。限制性立方样条分析结果显示,血浆miR-375水平与ACS预后明显相关(P<0.001),且呈线性关系(非线性检验,P=0.127)。与miR-375=2.62比较,患者miR-375>2.62时,预后不良风险增加。结论 ACS患者PCI术后血浆miR-375水平降低。PCI术后血浆miR-375水平升高与ACS预后不良有关,是ACS预后不良的独立危险因素。

Objective To explore the correlation between plasma microRNA-375(miR-375) level and prognosis in patients with acute coronary syndrome(ACS). Methods A total of 206 patients with ACS, who were admitted to the First Affiliated Hospital of Kunming Medical University of China during the period from March 2016 to April 2017 to receive percutaneous coronary intervention(PCI), were enrolled in this study.Real-time fluorescence quantitative polymerase chain reaction(PCR) method was used to detect the plasma miR-375 level in ACS patients, and its correlation with the prognosis of ACS patients was analyzed. Results The postoperative plasma miR-375 level in the poor prognosis group was higher than that in the good prognosis group, and the difference was statistically significant(P<0.05). The mean survival time in the low miR-375 group was longer than that in the high miR-375 group, and the difference was statistically significant(P<0.001). Cox multivariate analysis showed that family history of ACS and miR-375 level were independent risk factors for the prognosis of ACS patients(P<0.05). Restrictive cubic spline analysis indicated that plasma miR-375 level was significantly related to the prognosis of ACS patients(P <0.001), presenting a linear correlation between the two indicators(non-linear testing P=0.127). Compared with miR-375=2.62, when the patient’s miR-375 >2.62 the risk of poor prognosis would be increased. Conclusion The plasma miR-375 level in ACS patients is decreased after PCI. The increase of post-PCI plasma miR-375 level is related to the poor prognosis of ACS and is an independent risk factor for the poor prognosis of ACS.