超声引导下介入治疗对卵巢巧克力囊肿患者血清转录因子活化蛋白激酶B、糖类抗原125、白细胞介素-6的影响

Effect of ultrasound-guided interventional therapy on serum JUNB,CA125 and IL-6 in patients with ovarian chocolate cyst

目的探讨超声引导下介入治疗对卵巢巧克力囊肿患者血清转录因子活化蛋白激酶B(JUNB)、糖类抗原125(CA125)、白细胞介素-6(IL-6)的影响,为巧克力囊肿患者的预后评估提供一定的理论依据。方法前瞻性纳入2016年8月至2018年9月收治的96例卵巢巧克力囊肿患者为研究对象,均接受超声引导下介入治疗。在介入治疗前、治疗后6个月检测血清中JUNB、CA125、IL-6水平,同时收集患者治疗后6个月的随访信息,根据是否复发分为复发组(n=78)和未复发组(n=18),比较两组治疗前、治疗后3、6个月时血清中JUNB、CA125、IL-6的差异,并分析3个指标的变化趋势,同时运用受试者工作特征(ROC)曲线判断血清中JUNB、CA125、IL-6在评估患者预后中的价值,计算曲线下面积(AUC)、灵敏度和特异度。结果未复发治疗后6个月时血清JUNB、CA125、IL-6均呈下降趋势(P<0.05),而复发组仅在治疗后6个月有上升趋势(P<0.05)。JUNB在治疗前、治疗后3、6个月时的AUC分别为0.490、0.661、0.922;CA125分别为0.471、0.946、0.979;IL-6分别为0.519、0.647、0.852。其最佳截断值分别为1.752、64.82、46.62。结论超声引导下介入治疗可降低卵巢巧克力囊肿患者血清中JUNB、CA125、IL-6的水平,复发患者以上指标均有上升趋势,血清JUNB和IL-6可在一定程度上评估患者预后。

Objective To investigate the effect of ultrasound-guided interventional therapy on serum JUNB,CA125 and IL-6 in patients with ovarian chocolate cysts so as to provide a theoretical basis for the prognostic evaluation of patients with chocolate cysts.Methods A total of 96 patients with ovarian chocolate cysts,who were admitted to authors’hospital from August 2016 to September 2018,were enrolled in this prospective study.All patients underwent ultrasound-guided interventional treatment.Before and 6 months after treatment,the serum JUNB,CA125 and IL-6 levels were tested.The patients’follow-up information was collected at 6 months after treatment.Based on whether there was recurrence or not,the patients were divided into recurrent group(n=78)and non-recurrent group(n=18).The serum levels of JUNB,CA125 and IL-6 were tested before the treatment and 3,6 months after the treatment,the results were compared between the two groups.The variation tendency of the above three indexes were analyzed.By using the receiver operating curve(ROC),the prognostic values of serum JUNB,CA125 and IL-6 were evaluated.The area under the curve(AUC),sensitivity and specificity were calculated.Results The pre-treatment and 6-month post-treatment serum levels of JUNB,CA125 and IL-6 showed a downward trend in non-recurrent group(P<0.05),while the 6-month post-treatment serum levels of JUNB,CA125 and IL-6 showed an up-going trend in recurrent group(P<0.05).Before the treatment and 3,6 months after the treatment,the AUCs of serum levels of JUNB were 0.490,0.661 and 0.922 respectively,the AUCs of serum levels of CA125 were 0.471,0.946 and 0.979 respectively,and the AUCs of serum levels of IL-6 were 0.519,0.647 and 0.852 respectively.The serum levels of 6-month post-treatment JUNB,pre-treatment CA125 and 3-month post-treatment IL-6 had good sensitivity and specificity,and their optimal cut-off values were 1.752,64.82 and 46.62 respectively.Conclusion Ultrasound-guided interventional therapy can reduce the serum levels of JUNB,CA125 and IL-6 in patients with ovarian chocolate cysts.The above indexes in patients developing recurrence show an up-going trend.The serum levels of JUNB and IL-6 have certain sensitivity and specificity for the evaluation of prognosis.