卟啉类光敏剂的合成以及在光动力疗法中的研究进展

Synthesis of Porphyrin Photosensitizers and Research Progress in Photodynamic Therapy

卟啉类化合物作为一种有效的有机光敏剂,在光动力疗法中扮演着很重要的角色。其主要机理是吸收激光能量产生活性氧,从而达到杀灭肿瘤细胞的治疗目的。综述了卟啉类化合物的基本合成路线、三代卟啉类光敏剂的特点,以及近年来对卟啉类光敏剂的改性手段等。就目前卟啉类光敏剂在光动力疗法中的广泛运用来看,随着新型光敏剂的陆续开发,光动力疗法在临床治疗方面将会有突出的应用前景。

Porphyrins,as an organic photosensitizer in medicine,play a very important role in photodynamic therapy.Their main mechanism is to absorb laser energy to produce reactive oxygen species,so as to achieve therapeutic purposes.In this paper,the basic synthetic route,the characteristics of each generation of porphyrin photosensitizers and the scientific research of porphyrin photosensitizers are reviewed.At present,porphyrin photosensitizers are widely used in photodynamic therapy,and with the development of new photosensitizers,photodynamic therapy will have a prominent application prospect in clinical treatment.