美满霉素联合异维A酸对痤疮患者皮肤屏障功能及炎性因子的影响

Effect of minocycline combined with isotretinoin on skin barrier function and serum inflammatory factor in patients with acne

目的研究美满霉素联合异维A酸对痤疮患者皮肤屏障功能及血清炎性因子的影响。方法按随机数字表法将2017年3月至2019年7月济南市第三人民医院收治的88例痤疮患者分为参照组和观察组,各44例。参照组患者采用单一的异维A酸治疗,观察组患者采用美满霉素联合异维A酸治疗,两组患者均治疗14 d。比较两组患者治疗后的临床疗效;比较两组患者治疗前后皮肤屏障功能及血清肿瘤坏死因子-α(TNF-α)、超敏-C反应蛋白(hs-CRP)、白介素-6(IL-6)水平;比较两组患者治疗期间的不良反应。结果观察组患者治疗后临床总有效率(95.45%)高于参照组患者(77.27%);两组患者治疗后的经皮水分丢失(TEWL)、pH值及血清TNF-α、hs-CRP、IL-6水平较治疗前均降低,且观察组低于参照组;两组患者角质层含水量较治疗前均升高,且观察组高于参照组;治疗期间观察组患者的不良反应总发生率为9.09%,低于参照组患者的29.55%(均P<0.05)。结论美满霉素联合异维A酸治疗痤疮患者,可抑制炎症反应,改善临床疗效以及皮肤屏障功能,且安全性较好。

Objective To study the effects of minocycline combined with isotretinoin on skin barrier function and serum inflammatory factor in patients with acne.Methods 88 cases patients with acne admitted to The Third Hospital of Jinan from March 2017 to July 2019 were selected as the research objects,they were divided into the reference group and the observation group according to the random number table method.Patients in the reference group were treated with single isotretinoin,and patients in the observation group were treated with minocycline combined with isotretinoin.Patients in both groups were treated for 14 days.Compared the clinical efficacy of patients in the two groups after treatment;Compared the skin barrier function and serum tumor necrosis factor-α(TNF-α),high sensitivity-C-reactive protein(hs-CRP)and interleukin-6(IL-6)levels of patients in the two groups before and after treatment;Compared the occurrence of adverse reactions of patients between the two groups during the treatment.Results After treatment,the total clinical effective rate of patients in the observation group(95.45%)was higher than that of patients in the reference group(77.27%);Compared with before treatment,the transdermal water loss(TEWL),pH value and serum TNF-α,hs-CRP,IL-6 levels of patients in the two groups after treatment decreased,and the observation group was lower than the reference group;The water content of the stratum corneum of patients in the two groups increased,and the observation group was higher than the reference group;The total incidence of adverse reactions in the observation group during the treatment period was 9.09%,which was lower than 29.55%of patients in the reference group(all P<0.05).Conclusion The treatment of acne with minocycline combined with isotretinoin can effectively improve the clinical efficacy of acne patients,improve the skin barrier function of patients,and hais high security.